加味益脾镇惊散治疗维生素D缺乏性佝偻病脾虚肝旺型临床观察

发布时间：2018-03-28 10:31

本文选题：加味益脾镇惊散　切入点：小儿维生素D缺乏性佝偻病　出处：《黑龙江中医药大学》2017年硕士论文

【摘要】：目的:评估加味益脾镇惊散治疗小儿脾虚肝旺型维生素D缺乏性佝偻病的疗效。方法:将符合纳入标准的63例患有维生素D缺乏性佝偻病者,应用随机分组法,将其分别分为治疗组32例、对照组31例。治疗组给予加味益脾镇惊散口服,对照组予维生素D滴剂、碳酸钙D3颗粒口服,并对2组患儿家属进行宣教普及,配合全面细致的病情指导和护理。疗程均为8周。8周后进行综合疗效的评定,包括中医证候疗效、血清25-OH-D,钙、磷、碱性磷酸酶的变化情况,治疗前后单项中医症状积分(食少纳呆、精神)变化情况以及中医证候方面的改善情况。结果:1.在中医证候疗效方面,治疗组的总有效率达到93.75%,对照组的总有效率为90.32%,治疗组优于对照组。2.在血清25-OH-D、钙、磷、碱性磷酸酶方面,治疗后两组检验值改善情况比较,治疗后各组血清25-OH-D、钙、磷、碱性磷酸酶较治疗前明显改善;治疗后治疗组血清磷改善情况优于对照组。3.治疗后两组中医证候总积分、单项症状积分(食少纳呆、精神)方面改善情况对比,治疗组优于对照组。结论:1.加味益脾镇惊散可显著降低维生素D缺乏性佝偻病(脾虚肝旺型)患者的中医证候积分,可以减轻患儿食少纳呆、精神情况等中医症状,且其改善情况优于对照组。2.加味益脾镇惊散可改善维生素D缺乏性佝偻病(脾虚肝旺型)患儿的血清钙、磷、碱性磷酸酶、血清25-OH-D水平,防治佝偻病。
[Abstract]:Objective: to evaluate the therapeutic effect of Jiawei Yipi Zhenjingsan on vitamin D deficiency rickets in children with spleen deficiency and liver hyperactivity. Methods: 63 patients with vitamin D deficiency rickets who met the inclusion criteria were randomly divided into two groups. They were divided into treatment group (n = 32) and control group (n = 31). The treatment group was treated with Jiawei Yipi Zhen Jing San, the control group was given vitamin D drops and calcium carbonate D3 granules, and the families of the two groups were given education and education. The course of treatment was 8 weeks and 8 weeks later, the comprehensive curative effect was evaluated, including the curative effect of TCM syndrome, the changes of serum 25-OH-D, calcium, phosphorus, alkaline phosphatase, and so on. Before and after treatment, the changes of the single TCM symptom score (eating less, inpatient, mental) and the improvement of TCM syndromes. Results: 1. In the curative effect of TCM syndromes, The total effective rate of the treatment group was 93.75 and the total effective rate of the control group was 90.32. The treatment group was superior to the control group in the aspects of serum 25-OH-D, calcium, phosphorus and alkaline phosphatase. After treatment, the improvement of serum phosphorus in the treatment group was better than that in the control group. The treatment group is superior to the control group. Conclusion: the treatment group can significantly reduce the TCM syndrome score of vitamin D deficiency rickets (spleen deficiency liver flourishing type), and can alleviate the symptoms of the children, such as less food, less appetite, mental condition and so on. And the improvement was better than that of the control group .2.Jiawei Yipi Zhenjingsan could improve the serum calcium, phosphorus, alkaline phosphatase and serum 25-OH-D levels of children with vitamin D deficiency rickets (spleen deficiency liver flourishing type), and prevent and cure rickets.
【学位授予单位】：黑龙江中医药大学
【学位级别】：硕士
【学位授予年份】：2017
【分类号】：R272

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