难治性肾病综合征患儿环孢素A血药浓度监测回顾性分析

发布时间：2018-03-29 03:36

本文选题：环孢素A　切入点：治疗药物监测　出处：《中国新药杂志》2017年09期

【摘要】：目的:评价难治性肾病综合征患儿环孢素A(cyclosporine A,CsA)血药浓度的监测和临床用药情况。方法:对我院使用CsA治疗满3个月的45例肾病综合征患儿的288例/次符合入选条件的CsA血药浓度监测结果进行回顾性分析。结果:45例肾病综合征患儿共监测血药浓度288例/次,患儿首次监测时,CsA谷浓度以中浓度为主(50~100μg·L~(-1)),随着监测次数的增加,低浓度占比(50μg·L~(-1))逐渐增加。CsA日剂量和谷浓度呈显著性正相关;年龄对难治性肾病综合征患儿CsA血药浓度水平影响较大;合并使用地尔硫等CYP450抑制剂可明显影响CsA的血药浓度。结论:CsA血药浓度受较多因素影响,临床药师应对长程使用CsA的患儿及家长进行用药教育,促进患儿坚持进行血药浓度监测,以确保在安全剂量下有效治疗。
[Abstract]:Objective: to evaluate the monitoring of serum concentration of cyclosporine (A(cyclosporine) and cyclosporine (CSA) in children with refractory nephrotic syndrome. Methods: 288 cases of 45 children with nephrotic syndrome were treated with CsA for 3 months. Results the blood drug concentration of 45 children with nephrotic syndrome was monitored in 288cases every time. In the first time of monitoring, the concentration of CSA was 50 渭 g / L ~ (-1). With the increase of monitoring times, the ratio of low concentration to 50 渭 g / L ~ (-1) was increased gradually, and the daily dose of CSA was positively correlated with the concentration of CSA. Age had a great influence on the serum concentration of CsA in children with refractory nephrotic syndrome, and combined use of CYP450 inhibitors such as diltiazem could significantly affect the blood concentration of CsA. Conclusion the blood concentration of CsA is affected by many factors. The clinical pharmacists should educate the children and their parents on the use of CsA for a long time, and promote the children to insist on monitoring the blood drug concentration so as to ensure the effective treatment at the safe dose.
【作者单位】：南京医科大学附属儿童医院药学部;
【分类号】：R726.9

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