细菌合并病毒感染患儿给予抗生素治疗后恢复期淋巴细胞比率的参考范围研究

发布时间：2018-04-02 09:57

本文选题：淋巴细胞　切入点：细菌感染　出处：《中国全科医学》2017年S2期

【摘要】：目的建立细菌合并病毒混合感染给予抗生素治疗后处于恢复期的3个月~5岁患儿淋巴细胞比率的参考范围,并初步探讨其有关影响因素。方法收集高密市妇幼保健院2006年5月—2016年5月住院治疗经咽拭子细菌、病毒检测,确诊为细菌合并病毒感染的上呼吸道感染的3个月~5岁的患儿1 000例,收集全部研究对象的临床资料,应用SPSS 17.0对检验结果进行统计分析。结果本研究共收集3个月~5岁患儿1 000例,均为细菌合并病毒感染,其中男596例,女404例。3个月~1岁组恢复期淋巴细胞比率与其他年龄组比较,差异有统计学意义(P0.05);其他年龄组恢复期淋巴细胞比率比较,差异无统计学意义(P0.05)。入院前淋巴细胞比率、中性粒细胞比率与恢复期淋巴细胞比率有相关性(P0.05)。是否应用单磷酸阿糖腺苷、大环内酯类药物的患儿恢复期淋巴细胞比率比较,差异有统计学意义(P0.05)。Logistic回归分析显示,应用大环内酯类药物(OR=0.393,P=0.032)是促进恢复期淋巴细胞比率降低的因素。根据是否应用此类药物分别确定其参考范围,应用大环内酯类药物患儿恢复期淋巴细胞比率为(57.38 12.14)%,即(45.244%~69.516%);未应用大环内酯类药物患儿恢复期淋巴细胞比率为(63.74 10.09%)%,即(53.647%~73.833%)。结论是否应用大环内酯类对恢复期淋巴细胞比率有影响,参考范围应根据是否应用大环内酯类分别确立,便于指导临床。
[Abstract]:Objective to establish the reference range of lymphocyte ratio of children aged 5 years old who were in convalescence stage after antibiotic treatment with mixed infection of bacteria and virus, and to explore the influencing factors.The clinical data of all the subjects were collected and the results were statistically analyzed by SPSS 17.0.The difference was statistically significant (P 0.05), but there was no significant difference in other age groups (P 0.05).The lymphocyte ratio, neutrophil ratio and lymphocyte ratio in convalescent stage were correlated with the ratio of lymphocyte before admission (P 0.05).The percentage of lymphocytes in children with adenosine arabinomonophosphate and macrolides in convalescent stage was significantly higher than that in children treated with adenosine arabinoate monophosphate and macrolides. Logistic regression analysis showed that,The application of macrolide 0.393Pu 0.032 was a factor to promote the decrease of lymphocyte ratio in convalescent stage.Conclusion the effect of macrolides on lymphocyte ratio in convalescent stage should be determined according to whether macrolides are used or not, so as to guide clinical practice.
【作者单位】：潍坊医学院;高密市妇幼保健院;潍坊市人民医院;
【分类号】：R725.1

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