婴儿痉挛症患者血清、脑脊液S-100β和胶质纤维酸性蛋白水平观察及其相关性分析

发布时间：2018-04-18 22:21

本文选题：S-β蛋白 + 胶质纤维酸性蛋白　；参考：《山东医药》2017年35期

【摘要】：目的观察婴儿痉挛症患儿血清、脑脊液中星形胶质细胞分子标志物S-100β、胶质纤维酸性蛋白(GFAP)的相关性,并探讨其临床意义。方法选择婴儿痉挛症患者29例为观察组,同期收治的无中枢神经系统疾病的呼吸道感染患儿30例为对照组。采用ELISA法检测观察组、对照组患儿血清及观察组患儿脑脊液中S-100β、GFAP水平。结果观察组、对照组患儿血清S-100β水平分别为(0.80±0.16)、(0.37±0.07)μg/L,GFAP水平分别为(4.12±0.69)、(2.70±0.63)ng/L。观察组患儿血清S-100β和GFAP水平均高于对照组(P均0.05)。观察组患儿脑脊液S-100β水平为(1.08±0.23)μg/L,GFAP水平为(4.85±0.42)ng/L。观察组患儿血清S-100β水平和脑脊液S-100β水平呈正相关(r=0.883,P0.05),血清GFAP水平和脑脊液GFAP水平呈正相关(r=0.916,P0.05)。结论婴儿痉挛症患儿血清S-100β、GFAP水平升高,且与脑脊液S-100β、GFAP水平呈正相关。检测婴儿痉挛症患儿血清S-100β、GFAP水平有助于判断患儿脑脊液S-100β、GFAP水平,进而估计患儿中枢神经系统损伤程度。
[Abstract]:Objective to investigate the correlation of astrocyte molecular marker S-100 尾 and glial fibrillary acidic protein (GFAP) in serum and cerebrospinal fluid (CSF) of infants with infantile spasticity (infantile spasm), and to explore its clinical significance.Methods 29 cases of infantile spasm were selected as observation group and 30 cases of respiratory tract infection without central nervous system disease as control group.The levels of S-100 尾 -GFAP in cerebrospinal fluid (CSF) in the observation group, the control group and the control group were detected by ELISA method.Results in the observation group, the serum S-100 尾 levels in the control group were 0.80 卤0.16 卤0.37 卤0.07 渭 g / L respectively. The GFAP levels were 4.12 卤0.69 ng / L and 2.70 卤0.63 ng / L, respectively.The serum levels of S-100 尾 and GFAP in the observation group were higher than those in the control group (P < 0.05).The CSF S-100 尾 level was 1.08 卤0.23 渭 g / L and GFAP was 4.85 卤0.42 ng / L in the observation group.There was a positive correlation between serum S-100 尾 level and CSF S-100 尾 level in the observation group, and a positive correlation between serum GFAP level and cerebrospinal fluid GFAP level.Conclusion the level of serum S-100 尾 -GFAP in infants with infantile spasm is increased, and it is positively correlated with the level of S-100 尾 -GFAP in cerebrospinal fluid.The determination of serum S-100 尾 -GFAP level in infantile spasticity is helpful to judge the level of S-100 尾 -GFAP in cerebrospinal fluid and estimate the degree of central nervous system injury in children.
【作者单位】：安徽医科大学附属巢湖医院;
【基金】：安徽省卫计委科技攻关计划项目(08010302123)
【分类号】：R742.1

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