鼻病毒阳性患儿临床病症与呼吸道感染病情严重程度的相关性分析

发布时间：2018-04-20 02:02

本文选题：鼻病毒 + 呼吸道感染病　；参考：《中华医院感染学杂志》2017年22期

【摘要】：目的研究儿童发生呼吸道感染与鼻病毒的相关性,为防治鼻病毒感染提供重要的预防和治疗依据。方法选取2014年12月-2016年12月医院发生呼吸道感染的患儿226例,并使用RT-PCR对患儿进行人鼻病毒(HRV-A、HRV-B、HRV-C)等检测,并对产生阳性反应的标本行进化树分析、VP4/VP2衣壳蛋白质编码区基因和序列片段进行测定。结果在226例患者中,有44例患儿HRV检出阳性,阳性率19.47%,且性别间阳性率差异无统计学意义;普通感冒患儿的HRV阳性率为20.78%,支气管炎为17.24%,肺炎为19.83%,支气管哮喘未检测出阳性,不同疾病类型的阳性率差异均无统计学意义;HRV不同基因型与相同基因型的各核苷酸序列的同源性分别为55.5%~65.8%。结论 HRV是引起医院儿童急性呼吸道感染的重要因素,鼻病毒阳性患儿临床病症与呼吸道感染病情严重程度密切相关。
[Abstract]:Objective to study the correlation between respiratory tract infection and rhinovirus in children, and to provide an important basis for prevention and treatment of rhinovirus infection. Methods A total of 226 children with respiratory tract infection from December 2014 to December 2016 were selected and detected by RT-PCR. The genes and sequence fragments of the coding region of VP4 / VP2 capsid protein were determined by phylogenetic tree analysis. Results among 226 cases, 44 cases were positive for HRV, and the positive rate was 19.477.The positive rate of HRV was 20.78 in children with common cold, 17.24 in bronchitis, 19.83 in pneumonia, and no positive in bronchial asthma, the positive rate of HRV was 20.78 in children with common cold, 17.24 in bronchitis, 19.83 in pneumonia. There was no significant difference in positive rate among different disease types. The homology of nucleotide sequences between different genotypes of HRV and the same genotypes were 55.5% and 65.8%, respectively. Conclusion HRV is an important factor of acute respiratory tract infection in hospital children. The clinical symptoms of rhinovirus positive children are closely related to the severity of respiratory tract infection.
【作者单位】：浙江大学附属第二医院建德分院耳鼻咽喉科;
【基金】：浙江省医药卫生科技计划基金资助项目(2011KYA067)
【分类号】：R725.6

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