腹腔镜治疗对急性化脓性阑尾炎患儿血清slCAM-1与IL-8和TNF-α水平及免疫功能的影响

发布时间：2018-04-20 12:29

本文选题：腹腔镜 + 阑尾炎　；参考：《中华医院感染学杂志》2017年14期

【摘要】：目的研究腹腔镜治疗小儿急性化脓感染阑尾炎患者的血清可溶性细胞间粘附分子1(slCAM-1)、白细胞介素8(IL-8)以及肿瘤坏死因子-α(TNF-α)指标变化和对免疫功能影响的分析。方法选取2014年2月-2016年8月医院治疗的急性化脓感染的阑尾炎患儿213例,根据不同的治疗方案分为两组,对照组106例患者采用传统开腹手术治疗,观察组107例患者采用腹腔镜手术,治疗1周后比较两组患儿在治疗前后的血清slCAM-1、白细胞介素8(IL-8)以及肿瘤坏死因子-α(TNF-α)炎性指标和免疫细胞白细胞(WBC)、中性粒细胞(NEUT)、淋巴细胞(LY)的变化。结果观察组治疗1周后的血清slCAM-1为181.62±26.51ng/mL、IL-8为112.04±12.38pg/mL及TNF-α为51.72±3.25pg/mL,与对照组血清炎性指标值比较有明显下降;观察组治疗1周后免疫功能指标WBC为9.02±2.15×10~9/L、NEUT为6.04±2.46×10~9/L、LY为1.78±0.35×10~9/L明显低于对照组,以上数据两组比较差异均有统计学意义(P0.05)。结论腹腔镜手术治疗小儿急性化脓感染的阑尾炎,对患儿的血清slCAM-1、IL-8以及TNF-α指标水平有显著改善,并且对患者相关的免疫功能有积极影响,是一种对阑尾炎急性化脓感染治疗的高效、理想的术式方法。
[Abstract]:Objective to study the changes of serum soluble intercellular adhesion molecule (SICAM-1), interleukin-8 (IL-8) and tumor necrosis factor- 伪 (TNF- 伪) in children with acute suppurative appendicitis treated by laparoscopy and their effects on immune function. Methods 213 children with acute suppurative appendicitis treated in hospital from February 2014 to August 2016 were divided into two groups according to different treatment schemes. 106 patients in the control group were treated with traditional open surgery. In the observation group, 107 patients were treated with laparoscopic surgery. The changes of serum slCAM-1, interleukin-8 (IL-8), tumor necrosis factor- 伪 (TNF- 伪), WBCU, neutrophil neutrophil neutrophil (neutrophil neutrophil neutrophil neutum) and tumor necrosis factor- 伪 (TNF- 伪) were compared between the two groups one week after treatment. Results the serum slCAM-1 and TNF- 伪 were 181.62 卤26.51ng / mL IL-8 and 51.72 卤3.25pg / mL, respectively, which were significantly lower than those of the control group, and the WBC of the observation group was 9.02 卤2.15 脳 109nLNEUT (6.04 卤2.46 脳 109nL / L, 1.78 卤0.35 脳 109L / L) after one week of treatment, which was significantly lower than that of the control group (P < 0.05). The differences between the two groups were statistically significant (P 0.05). Conclusion Laparoscopic surgery for appendicitis in children with acute suppurative infection can significantly improve the serum levels of slCAM-1 IL-8 and TNF- 伪, and have a positive effect on the immune function of the patients. It is an effective and ideal method for the treatment of acute purulent appendicitis.
【作者单位】：邢台市人民医院小儿外科;
【分类号】：R726.5

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