隐睾患儿睾丸功能的评估

发布时间：2018-04-22 01:08

本文选题：隐睾 + 间质细胞　；参考：《上海交通大学学报(医学版)》2017年01期

【摘要】：目的·探讨不同年龄及不同类型隐睾对睾丸间质细胞、支持细胞功能的影响。方法·将病例组101例隐睾患儿按年龄、睾丸位置及隐睾程度分类,对照组为非泌尿系统疾病、外生殖器正常且无第二性征发育的男童。进行LHRH激发试验、h CG激发试验、血清抗苗勒管激素(AMH)及抑制素B(Inh B)水平检测。结果·病例组患儿h CG激发后的睾酮(T)值在各年龄亚组间比较,0.5~1岁组明显高于其余年龄亚组;病例组AMH和Inh B值均明显低于对照组。高位隐睾组h CG激发后的T值、AMH和Inh B值均明显低于低位隐睾组。h CG激发后T值及AMH和Inh B在单侧隐睾与双侧隐睾组间比较,差异均无统计学意义。结论·在青春期前隐睾最先影响睾丸支持细胞功能,隐睾对间质细胞功能的影响在1岁内无严重影响。隐睾对睾丸功能的影响与睾丸位置高低有关,与单双侧隐睾无关。
[Abstract]:Objective to investigate the effects of different ages and types of cryptorchidism on the function of Leydig cells and Sertoli cells. Methods 101 children with cryptorchidism were classified according to age, location of testis and degree of cryptorchidism. LHRH stimulation test and hCG stimulation test were carried out, and the levels of serum anti-Mullerian hormone and inhibin B(Inh B were detected. Results the value of testosterone T after hCG stimulation was significantly higher in the 1-year-old group than that in the other subgroups, and the values of AMH and Inh B in the case group were significantly lower than those in the control group. The T values and Inh B values of hCG in high cryptorchidism group were significantly lower than those in low cryptorchidism group. H CG group and AMH and Inh B were not significantly different between unilateral cryptorchidism group and bilateral cryptorchidism group. Conclusion the primary effect of cryptorchidism on testicular Sertoli cell function is before puberty, but the influence of cryptorchidism on interstitial cell function is not serious within 1 year old. The influence of cryptorchidism on testicular function is related to the position of testis, but not to the unilateral and bilateral cryptorchidism.
【作者单位】：上海市儿童医院上海交通大学附属儿童医院内分泌科;上海市儿童医院上海交通大学附属儿童医院检验科;
【基金】：上海市科学技术委员会基金(12411952408,13495810300) 上海申康医院发展中心项目(SHDC12015111)~~
【分类号】：R726.9

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