维生素A浓度与儿童热性惊厥的关系探讨

发布时间：2018-05-02 12:32

本文选题：热性惊厥 + 维生素A　；参考：《重庆医科大学》2015年硕士论文

【摘要】：目的：探讨热性惊厥(febrile seizures，FS)患儿血清维生素A(vitamin A,VA)浓度的变化及与其临床特征的关系。方法：1.收集了在重庆医科大学附属儿童医院神经内科住院治疗的49例FS儿童(研究组)和29例癫痫儿童、49例儿保科体检的健康儿童的临床资料,并采用高效液相色谱法(High performance liquid chromatography,HPLC)对FS急性期、恢复期、29例癫痫儿童及49例健康儿童血清VA进行测量。2.统计分析49例儿童VA与个人资料、惊厥发作特点间是否具有差异性。3.分析比较49例FS儿童急性期、29例癫痫儿童、49名健康儿童血浆VA水平。4.比较18例FS儿童急性期、恢复期与健康儿童血清VA浓度的变化。5.所有数据均经SPSS13.0统计学软件进行统计分析,P0.05表示具有统计学意义。结果：1.在49例纳入研究的FS患儿,其中年龄在6个月-3岁间的有36例(73.5%),男：女为1.8：1。在FS分类中,最多见的类型为复杂型FS,约为65.3%。2.49例FS者个人资料(年龄、性别、孕周、生产方式、居住区域)组间VA浓度水平无显著变化。3.49例FS的不同的惊厥发作次数、发作类型、持续时间与VA浓度水平变化无明显差异性,且惊厥发作次数、持续时间与VA浓度水平无相关性。4.FS急性期VA的浓度0.50± 0.18umol/L较癫痫儿童VA浓度0.83±0.12umol/L及正常同龄儿童VA浓度0.87± 0.13umol/L均显著降低,具有统计学差异(P0.05),癫痫儿童与健康儿童相比VA浓度无明显差异性(P0.05)。5.FS急性期维生素A缺乏(vitamin A deficiency, VAD)占85.7%,癫痫儿童中VAD占6.9%,健康儿童中VAD占6.1%,FS急性期VAD检出率明显高于癫痫儿童及健康儿童,具有统计学差异(P0.05),癫痫儿童VAD检出率与健康儿童相比无明显差异性(P0.05)。6.在49例FS中,有18例FS在恢复期复查了VA浓度,为0.81±0.1 lumol/L,较急性期VA浓度0.48±0.12umol/L显著升高,并具有统计学差异(P0.05),与正常儿童相比VA浓度无显著差异(P0.05)。结论：小儿热性惊厥急性期血清中维生素A浓度有所降低,随着疾病的恢复,维生素A的浓度逐渐上升,提示维生素A可能参与影响热性惊厥的发生,但其浓度水平不影响惊厥的发作次数、形式、持续时间。
[Abstract]:Objective: to investigate the changes of serum vitamin A vitamin (VA) concentration in children with febrile seizuresa (FSs) and its relationship with clinical features. Method 1: 1. The clinical data of 49 FS children (study group) and 49 healthy children undergoing physical examination in pediatric care department of Chongqing Medical University affiliated Children Hospital were collected. The serum VA of 29 epileptic children and 49 healthy children were measured by high performance liquid chromatography (HPLC). Statistical analysis of 49 children with VA and personal data, convulsive seizure characteristics of the difference between the. 3. 3. The plasma VA levels of 49 FS children with acute epilepsy and 49 healthy children were analyzed and compared. The changes of serum VA concentration in 18 FS children in acute stage, convalescence stage and healthy children were compared. 5. 5. All data were statistically significant by SPSS13.0 statistical software for statistical analysis. The result is 1: 1. Of the 49 FS children enrolled in the study, 36 were aged between 6 months and 3 years old (male: female: 1.8: 1). In the FS classification, the most common type was complex FSs, about 65.33.2.49 FS personal data (age, sex, gestational age, mode of production, living area) had no significant change in VA concentration. 3.49 FS patients had different convulsions. There was no significant difference between the onset type, duration and VA concentration, and the number of seizures. There was no correlation between the duration of VA and VA concentration. 4. The VA concentration of 0.50 卤0.18umol/L in acute phase of FS was significantly lower than that in epileptic children (0.83 卤0.12umol/L) and normal children of the same age (0.87 卤0.13umol/L). There was no significant difference in VA concentration between epileptic children and healthy children. The positive rate of VAD in epileptic children was significantly higher than that in healthy children in acute phase. For epileptic children and healthy children, There was no significant difference in the detection rate of VAD between epileptic children and healthy children. Of 49 FS patients, 18 patients had VA concentration (0.81 卤0.1 lumol / L) in recovery phase, which was significantly higher than that in acute stage (0.48 卤0.12umol/L). There was no significant difference in VA concentration between FS and normal children (P 0.05). Conclusion: the concentration of vitamin A in the serum of children with febrile convulsion decreased, and the concentration of vitamin A increased gradually with the recovery of the disease, suggesting that vitamin A may be involved in the occurrence of febrile convulsion. However, the level of its concentration does not affect the number, form and duration of seizures.
【学位授予单位】：重庆医科大学
【学位级别】：硕士
【学位授予年份】：2015
【分类号】：R720.597

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