金银花颗粒联合人免疫球蛋白治疗手足口病患儿的疗效及对血清细胞因子和免疫功能的影响

发布时间：2018-05-05 07:08

本文选题：金银花颗粒 + 人免疫球蛋白　；参考：《中华医院感染学杂志》2017年20期

【摘要】：目的探讨金银花颗粒联合人免疫球蛋白治疗手足口病患儿的疗效及对血清细胞因子和免疫功能的影响。方法选取2015年6月-2017年1月于医院就诊的136例手足口病患儿为研究对象,采用随机数字表法分为对照组及观察组,各68例;两组患儿均于入院后密切观察病情,维持水电解质平衡,给予退热、抗感染、抗病毒等治疗;对照组患儿给予静脉注射人免疫球蛋白,观察组在对照组基础上口服金银花颗粒,两组疗程均为5d,比较两组疗效,主要症状、体征改善情况,治疗前后血清细胞因子和免疫功能指标变化。结果观察组总有效率91.18%显著高于对照组75.00%(P0.05);两组治疗前血清CRP、IL-17、TNF-α比较无统计学差异;观察组治疗后口腔疱疹消退时间、体温恢复时间及皮疹消退时间分别为(2.65±0.78)d、(1.59±0.47)d及(2.67±0.51)d均优于对照组(3.94±1.04)d、(2.79±0.68)d及(3.75±0.72)d(P0.05);观察组治疗后血清C-反应蛋白(CRP)、白细胞介素-17(IL-17)、肿瘤坏死因子-α(TNF-α)水平显著低于对照组(P0.05);两组治疗前免疫球蛋白A(IgA)、IgG、IgM、CD_3~+、CD_4~+、CD_4~+/CD_8~+比较无统计学差异;治疗后观察组IgA、IgG、CD_3~+、CD_4~+、CD_4~+/CD_8~+显著高于对照组(P0.05);两组治疗后IgM比较无统计学差异。结论金银花颗粒联合人免疫球蛋白治疗小儿手足口病疗效显著,可降低血清CRP、IL-17、TNF-α细胞因子水平,改善患者免疫功能。
[Abstract]:Objective to investigate the effect of honeysuckle granule combined with human immunoglobulin on the serum cytokines and immune function in children with hand-foot-mouth disease. Methods 136 children with HFMD from June 2015 to January 2017 were randomly divided into control group (n = 68) and observation group (n = 68). Maintain the balance of water and electrolyte, give antifebrile, anti-infection, antiviral treatment, etc. In the control group, children were given intravenous injection of human immunoglobulin, and the observation group took honeysuckle granules orally on the basis of the control group. The course of treatment in both groups was 5 days, and the curative effects were compared between the two groups. The main symptoms, signs, changes of serum cytokines and immune function before and after treatment. Results the total effective rate of observation group (91.18%) was significantly higher than that of control group (75.00%) (P 0.05), there was no statistical difference between the two groups before and after treatment. The recovery time of body temperature and the time of skin rash regression were 2.65 卤0.78 d and 2.67 卤0.51d, respectively, which were significantly higher than those of control group (3.94 卤1.04d, 2.79 卤0.68d, 3.75 卤0.72dU, P 0.05), and the levels of serum C-reactive protein (CRP), interleukin-17 (IL-17), tumor necrosis factor- 伪 TNF- 伪 were significantly lower in the observation group than in the control group (P 0.05) before and after the treatment, and the levels of serum C-reactive protein (CRP), interleukin-17 (IL-17), tumor necrosis factor- 伪 (TNF- 伪) were significantly lower than those in the control group (P 0.05). There was no statistical difference in the comparison of immunoglobulin A (IgA) and IgG / IgM (CD4 / CD4 / CD8) between the two groups. After treatment, the IgM of the observation group was significantly higher than that of the control group (P 0.05), and there was no significant difference between the two groups after treatment. Conclusion Flos Lonicerae granules combined with human immunoglobulin is effective in the treatment of HFMD in children. It can reduce the level of serum CRP IL-17 TNF- 伪 cytokines and improve the immune function of the patients.
【作者单位】：台州市中心医院放射科;台州市中心医院儿科;杭州市儿童医院放射科;
【基金】：浙江省医药卫生一般研究计划基金资助项目(2014KYB278)
【分类号】：R725.1

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