377例新生儿乙肝病毒母婴传播阻断效果及相关因素分析

发布时间：2018-05-08 05:25

  本文选题：乙型肝炎病毒 + 母婴传播　； 参考：《现代预防医学》2017年13期

【摘要】：目的研究乙肝免疫球蛋白(hepatitis B immunoglobulin,HBIG)和10μg重组酵母乙肝疫苗(hepatitis B vaccine,Hep B)联合应用阻断乙肝病毒(hepatitis B virus,HBV)母婴传播效果。方法 2013-2015年以居住在北京市海淀区、乙肝表面抗原(hepatitis B surface antigen,HBsAg)阳性母亲所生、出生时进行过HBV母婴阻断的儿童为研究对象。通过问卷获得被调查儿童的人口学状况、出生医院、HBIG和Hep B接种情况,以及母亲分娩前乙肝e抗原情况。采集儿童静脉血标本5ml,检测HBsAg、乙肝表面抗体(hepatitis B surface antibody,抗-HBs)、乙肝核心抗体(hepatitis B surface antibody,抗-HBc)。计算不同特征儿童的HBsAg和抗-HBs阳性率,并比较其差异。结果共纳入分析儿童377人,HBsAg均为阴性,抗-HBs阳性率为91.25%(344/377)。单因素分析显示,采血距第3剂Hep B(Hep B3)不同间隔儿童抗-HBs阳性率(94.72%VS 70.91%)差异有统计学意义(校正=30.432,P0.001);多因素logistic回归分析显示,抗-HBs是否阳性与HBIG接种剂量和采血距第3剂Hep B(Hep B3)间隔时间有关,与出生时接种100IU HBIG的儿童(92.56%)相比,接种200IU的儿童抗-HBs阳性率(85.29%)低(OR=0.352,95%CI:0.148~0.834,P=0.018);与采血距Hep B3间隔3年儿童(94.72%)相比,采血间隔≥3年儿童的抗-HBs阳性率(70.91%)低(OR=0.119,95%CI:0.054~0.262,P0.001)。结论≥100IU HBIG和10μg重组酵母Hep B联合应用可有效阻断HBV母婴传播;儿童抗-HBs阳性率随时间下降,特别是3年后下降较明显,需对HBsAg阳性母亲所生儿童进行HBV血清学监测,根据结果决定是否需要加强免疫。
[Abstract]:Objective to study the effect of hepatitis B immunoglobulin B (HBIGG) combined with 10 渭 g recombinant yeast hepatitis B vaccine (hepatitis B accine Hep Bep) on blocking mother-to-child transmission of hepatitis B virus (HBV). Methods Children who were born with hepatitis B surface antigen-HBsAg positive mothers living in Haidian District of Beijing from 2013 to 2015 and who had been blocked from mother to child by HBV were studied. The demographic status of the children, the inoculation of HBIG and Hep B in the birth hospital, and the hepatitis B antigen before delivery were obtained by questionnaire. The blood samples of children were collected to detect HBsAg, hepatitis B surface antibody, anti-HBsAg, hepatitis B surface antibody, anti-HBcTc. The positive rates of HBsAg and anti-HBs in children with different characteristics were calculated and compared. Results all 377 children were negative for HBsAg, and the positive rate of anti-HBs was 91.25%. Univariate analysis showed that the positive rate of anti-HBs was 94.72VS70.91in children with different intervals from the 3rd dose of Hep B(Hep B3). The positive rate of anti-HBs in the children inoculated with 200IU was lower than that in children inoculated with 200IU 0.352c95CIW 0.1480.34P0.01818, compared with the children who took blood from Hep B3 three years later, compared with the children who took blood at the interval of 3 years from Hep B3, the positive rate of anti-HBs in the children inoculated with 200IU was lower than that of the children who took blood from Hep B3. The positive rate of anti-HBs in children with blood sampling interval 鈮，

本文编号：1860125