粉尘螨滴剂与匹多莫德联合应用对小儿变应性鼻炎伴哮喘的疗效及机制

发布时间：2018-05-08 13:46

本文选题：变应性鼻炎 + 哮喘　；参考：《山东医药》2017年04期

【摘要】：目的观察粉尘螨滴剂联合匹多莫德对小儿变应性鼻炎伴哮喘的疗效,探讨其作用机制。方法 60例变应性鼻炎伴哮喘患儿随机分为观察组和对照组,每组30例。两组均行常规治疗,舌下含服粉尘螨滴剂;治疗组在此基础上口服匹多莫德,治疗前及治疗12周时评价鼻炎及哮喘严重程度,检测血清Ig M、Ig G、Ig A及CD3~+、CD4~+、CD4~+/CD8~+,测定血清CRP、IL-8、TNF-α及第1秒用力呼气容积(FEV1)、最大呼气峰流速(PEF)、用力呼气25%流速(PEF25)、用力呼气50%流速(PEF50)、用力呼气75%流速(PEF75)。结果两组治疗12周时,鼻炎和哮喘症状评分均较治疗前降低,血清Ig M、Ig G、Ig A及CD3~+、CD4~+、CD4~+/CD8~+均较治疗前升高,CD8~+均较治疗前降低,血清CRP、IL-8、TNF-α水平均较治疗前降低,FEV1、PEF、PEF25、PEF50、PEF75均较治疗前下降,同组治疗前后比较P均0.05;观察组治疗后上述指标变化均较对照组显著(P均0.05)。结论粉尘螨滴剂联合匹多莫德治疗变应性鼻炎伴哮喘患儿效果肯定,提高患儿免疫功能、减轻炎症反应、促进肺功能改善可能是其作用机制。
[Abstract]:Objective to observe the effect of Dermatophagoides farinae drop combined with pidomod on allergic rhinitis with asthma in children and explore its mechanism. Methods 60 children with allergic rhinitis and asthma were randomly divided into observation group and control group with 30 cases in each group. Both groups were given routine treatment, sublingual administration of Dermatophagoides farinae drops, on the basis of oral administration of pidomod, the severity of rhinitis and asthma was evaluated before treatment and 12 weeks after treatment, and the serum levels of IgMN Ig GG A and CD3 ~ + CD4 ~ + CD4 ~ / CD8 ~, were detected. The levels of serum CRP IL-8 TNF- 伪 and FEV1a were measured. The peak expiratory flow rate was PEF1, the forced expiratory flow rate was 25% PEF25, the forced expiratory flow rate was 50%, and the forced expiratory flow rate was 75%. Results at 12 weeks after treatment, the scores of symptoms of rhinitis and asthma in both groups were lower than those before treatment. The levels of serum IgA and CD3 ~ + CD4 ~ / CD8 ~-were lower than those before treatment, and the levels of serum CRP IL-8 ~ + TNF- 伪 were lower than those before treatment. The changes of above indexes in the observation group were significantly higher than those in the control group before and after treatment (P 0.05). Conclusion Dermatophagoides farinae drop combined with pidomod is effective in the treatment of children with allergic rhinitis and asthma. It may be a mechanism to improve the immune function, alleviate inflammation and improve lung function in children with allergic rhinitis and asthma.
【作者单位】：四川省医学科学院四川省人民医院;
【分类号】：R765.21;R725.6

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