血清CD64、CD54、sTREM-1及炎性因子在儿童细菌性肺炎进展中的表达水平分析

发布时间：2018-05-15 00:38

本文选题：CD + CD　；参考：《中华医院感染学杂志》2017年13期

【摘要】：目的探究血清CD64、CD54、sTREM-1及炎性因子在儿童细菌性肺炎进展中的表达情况分析。方法选取医院2012年1月-2015年12月收治的细菌性肺炎患儿114例设为观察组,同期医院接受健康检查的儿童120名设为对照组,收集观察组患儿痰液行痰培养及药敏试验,抽取两组儿童静脉血,检测CD64、CD54、sTREM-1、CRP、TNF-α及IL-6水平。结果 114例细菌性肺炎的患者痰培养共检出病原菌132株,其中革兰阳性菌47株,革兰阴性菌85株;观察组血清中CD64、CD54、sTREM-1、CRP、TNF-α及IL-6均明显高于对照组水平,差异有统计学意义(P0.05)。结论血清中CD64、CD54、sTREM-1及炎性因子含量与儿童发生细菌性肺炎有密切的相关性,可以作为预测疾病发生发展的指标,并且应当在第一时间行痰液培养,发现病原菌,精准选用合适的抗菌药物,提高早期治疗效果。
[Abstract]:Objective to investigate the expression of serum CD64, CD54, TREM-1 and inflammatory factors in children with bacterial pneumonia. Methods 114 children with bacterial pneumonia from January 2012 to December 2015 were selected as observation group and 120 children who received health examination in hospital as control group. Sputum culture and drug sensitivity test were performed in observation group. The levels of TNF- 伪 and IL-6 in two groups were measured. Results 132 strains of pathogenic bacteria were detected in the sputum culture of 114 patients with bacterial pneumonia, of which 47 were Gram-positive bacteria and 85 were Gram-negative bacteria, and the serum levels of CD64TREM-1CRPN- 伪 and IL-6 in the observation group were significantly higher than those in the control group (P 0.05). Conclusion there is a close correlation between the levels of serum CD64TREM-1 and inflammatory factors in children with bacterial pneumonia, which can be used as an index to predict the occurrence and development of the disease, and sputum culture should be carried out in the first time to find the pathogenic bacteria. Accurate selection of appropriate antimicrobial agents to improve the early treatment effect.
【作者单位】：山东省临沭县人民医院儿内科;青岛市第三人民医院妇产科;
【基金】：青岛市2013医药科研指导计划基金资助项目(WSZD060)
【分类号】：R725.6

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