甲泼尼龙对儿童难治性肺炎支原体肺炎疗效和安全性meta分析

发布时间：2018-05-16 05:13

  本文选题：甲泼尼龙 + 难治性肺炎支原体肺炎　； 参考：《安徽医科大学》2017年硕士论文

【摘要】：目的探讨甲泼尼龙辅助治疗儿童难治性肺炎支原体肺炎(Refractory Mycoplasma pneumoniae pneumonia,RMPP)的疗效及安全性,以指导临床用药。方法分别检索Pubmed、Ovid、ELSEVIER ScienceDirect(SDOS)数据库、中国生物医学文献数据库、中国知网和万方数据库,英文全文检索refractory mycoplasma pneumoniae pneumonia,中文全文检索难治性肺炎支原体肺炎和甲泼尼龙,检索的起止时间为建库至2016年10月。依据纳入及排除标准筛选文献、资料,获得甲泼尼龙治疗儿童RMPP的RCT文献,进行文献质量评估后用Renman5.3软件进行Meta分析。结果检索到相关文献904篇,最终纳入29篇RCT文献进行Meta分析。Meta分析结果提示甲泼尼龙治疗儿童RMPP有效,可明显缩短住院时间(MD=-4.05(95%CI:-4.09~-3.20,P0.00001)),血清C-反应蛋白(CRP)水平亦明显低于对照组(MD=-23.21(95%CI:-31.63~-14.79,P0.00001)),并能明显缩短体温恢复时间(MD=-3.12(95%CI:-3.57~-2.67,P0.00001))、肺部Up音消失时间(MD=-3.56(95%CI:-4.40~-2.73,P0.00001))、咳嗽消失时间(MD=-3.43(95%CI:-4.27~-2.59,P0.00001)),提高临床有效率(OR=5.11(95%CI:3.58~7.31),P0.00001)。仅有少数轻微不良反应。结论在大环内酯类抗菌药物抗感染的基础上加用甲泼尼龙辅助治疗儿童RMPP疗效显著,且安全性较高。
[Abstract]:Objective to evaluate the efficacy and safety of methylprednisolone in the treatment of refractory mycoplasma pneumoniae pneumonia (Refractory Mycoplasma pneumoniae) in children. Methods Pubmedus Ovidago ELSEVIER ScienceDirect SDOS database, Chinese biomedical literature database, China Zhiwang database and Wanfang database were searched respectively. The refractory mycoplasma pneumoniae pneumonia, Chinese full-text search was used to search the refractory mycoplasma pneumoniae pneumonia and methylprednisolone respectively. The start and end of the search is until October 2016. According to the inclusion and exclusion criteria, the RCT literature of methylprednisolone for children with RMPP was obtained. The literature quality was evaluated and Meta analysis was performed with Renman5.3 software. Results 904 literatures were retrieved and 29 articles of RCT were included. The results of Meta analysis and Meta-analysis showed that methylprednisolone was effective in the treatment of RMPP in children. 鍙�鏄庢樉缂╃煭浣忛櫌鏃堕棧�

本文编号：1895592