硫酸镁雾化吸入对儿童肺功能的影响

发布时间：2018-05-21 06:27

本文选题：硫酸镁 + 雾化　；参考：《重庆医科大学》2012年硕士论文

【摘要】：目的观察硫酸镁雾化是否能改善乙酰胆碱激发后的哮喘患儿肺功能，并与单用沙丁胺醇雾化及二者联合雾化进行比较。方法收集2011年11月-2012年3月到重庆医科大学附属儿童医院复诊的哮喘患儿84例，随机分为三组，，均进行肺功能激发，然后用不同药物行支气管舒张试验：（1）硫酸镁组：雾化吸入等渗硫酸镁溶液（7.5%，含硫酸镁150mg）2ml；（2）沙丁胺醇组：雾化吸入沙丁胺醇溶液(含沙丁胺醇2.5mg)2ml；（3）硫酸镁+沙丁胺醇组：雾化吸入硫酸镁+沙丁胺醇混合溶液(含硫酸镁150mg+沙丁胺醇2.5mg）2.5ml。观察各组药物雾化吸入后10分钟、20分钟肺功能（FEV1、PEF）改变情况。结果 1.各组雾化吸入不同舒张药物后肺功能均有显著上升，比较各组舒张后的肺功能值无显著统计学差异（P0.05），但沙丁胺醇组分别与硫酸镁组、硫酸镁+沙丁胺醇组舒张试验后10分钟FEV1及PEF上升的百分比有显著统计学差异（P0.05）； 2.各组内不同时间段比较，硫酸镁组与沙丁胺醇组舒张试验后的肺功能较激发后的肺功能有显著统计学差异（P0.05），但硫酸镁+沙丁胺醇组无显著统计学差异（P0.05）。结论单用硫酸镁雾化吸入有支气管扩张作用，雾化吸入后10分钟内对FEV1和PEF的改善效果不如单用沙丁胺醇好，但总体两者无明显差别。硫酸镁+沙丁胺醇联合雾化吸入虽有支气管扩张效应，但本试验不能明确说明二者联合是否具有协同效应。
[Abstract]:Purpose To observe whether magnesium sulfate atomization can improve lung function of asthmatic children after acetylcholine stimulation and compare it with salbutamol alone and combined atomization. Method From November 2011 to March 2012, 84 children with asthma were randomly divided into three groups. Then bronchodiastolic test was performed with different drugs: magnesium sulfate group: aerosol inhalation of magnesium sulfate solution 7.5, containing magnesium sulfate 150 mg / g 2ml / L) salbutamol group: atomized inhalation of salbutamol solution (containing 2.5 mg / g salbutamol) magnesium salbutamol sulfate group Aerosol inhalation of magnesium salbutamol sulfate mixed solution (containing magnesium sulfate 150mg salbutamol 2.5 mg / L 2.5 ml. The changes of FEV 1 and PEF were observed 10 minutes and 20 minutes after inhalation. Result 1. The pulmonary function of each group was significantly increased after inhaling different vasodilators, and there was no significant difference in pulmonary function between the groups after inhalation. However, salbutamol group and magnesium sulfate group, respectively, had no significant difference in the value of pulmonary function after aerosol inhalation, but salbutamol group and magnesium sulfate group respectively. The percentage of increase of FEV1 and PEF in magnesium salbutamol sulfate group was significantly higher than that in control group 10 minutes after diastolic test (P 0.05). 2. There was significant difference in pulmonary function between magnesium sulfate group and salbutamol group after diastolic test (P 0.05), but there was no significant difference between magnesium sulfate group and salbutamol group (P 0.05). Conclusion Magnesium sulfate atomized inhalation alone had bronchiectasis effect, and the improvement of FEV1 and PEF within 10 minutes after inhalation was not as good as salbutamol alone, but there was no significant difference between the two groups. Although the combined inhalation of magnesium salbutamol sulfate has bronchiectasis effect, it is not clear whether the combination of the two has synergistic effect.
【学位授予单位】：重庆医科大学
【学位级别】：硕士
【学位授予年份】：2012
【分类号】：R725.6

【参考文献】