缺氧缺血性脑病早产儿血清tau蛋白、ACTA、NSE水平与神经发育的关系

发布时间：2018-05-25 17:46

本文选题：缺氧缺血性脑病 + 早产儿　；参考：《山东医药》2017年44期

【摘要】：目的探讨缺氧缺血性脑病(HIE)早产儿血清tau蛋白、激活素A(ACTA)及神经特异性烯醇化酶(NSE)水平变化及其与神经发育的关系。方法选取早产儿150例,其中并发HIE 60例(HIE组)、未并发HIE 90例(对照组),HIE组严重程度为轻度15例、中度28例、重度17例。两组分别于出生后7天检测血清tau蛋白、ACTA及NSE水平,出生后7、14、28天进行新生儿神经行为(NBNA)评分,出生后3、6个月采用婴幼儿发育量表检测智力发育指数(MDI)、运动发育指数(PDI)。分析HIE组血清tau蛋白、ACTA、NSE水平与NBNA评分、MDI、PDI的关系。结果 HIE组血清tau蛋白、ACTA、NSE水平均高于对照组(P均0.01),轻、中、重度HIE早产儿血清tau蛋白、ACTA、NSE水平依次升高(P均0.05)。HIE组出生后7、14、28天NBNA评分均低于对照组(P均0.05),出生后3、6个月MDI、PDI均低于对照组(P均0.05)。HIE早产儿血清tau蛋白、ACTA、NSE水平与NBNA评分、MDI、PDI均呈负相关(P均0.05)。结论 HIE早产儿血清tau蛋白、ACTA及NSE水平升高,三者水平变化可用于评估患儿疾病严重程度及神经发育情况。
[Abstract]:Objective to investigate the changes of serum tau protein, activin A (AC) and neuron-specific enolase (NSE) levels in premature infants with hypoxic-ischemic encephalopathy (HIE) and their relationship with neurodevelopment. Methods A total of 150 premature infants were selected, including 60 cases with HIE and 90 cases without HIE (control group: mild 15 cases, moderate 28 cases, severe 17 cases). The levels of serum tau protein ACTA and NSE were measured on the 7th day after birth, and the neurobehavioral status of the newborn was evaluated at 1428 days after birth. The intellectual development index (MDI) and motor development index (PDI) were measured by the infant development scale at 3 and 6 months after birth. To analyze the relationship between the level of serum tau protein and NBNA score in HIE group. Results the serum tau protein level in HIE group was higher than that in control group (P < 0.01). The serum tau protein level of severe HIE premature infants was increased in turn. The NBNA scores in the 0.05).HIE group were lower than those in the control group on day 7, 1428, and were lower than those in the control group at 3 and 6 months after birth. They were lower than those in the control group at 3 and 6 months after birth. The level of tau protein and the NBNA score of 0.05).HIE preterm infants in the control group were lower than those in the control group. There was a negative correlation between PDI and PDI (P = 0.05). Conclusion the levels of serum tau protein ACTA and NSE in preterm infants with HIE are increased. The changes of ACTA and NSE levels can be used to evaluate the severity of disease and neurological development in children with HIE.
【作者单位】：邢台市人民医院;
【基金】：邢台市科技计划项目(2015ZC069)
【分类号】：R742

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