基础血清黄体生成素水平对女孩中枢性性早熟诊断价值的探讨

发布时间：2018-05-26 12:51

本文选题：基础黄体生成素 + 中枢性性早熟　；参考：《中国当代儿科杂志》2017年07期

【摘要】：目的评价基础血清黄体生成素(LH)对女性中枢性性早熟(CPP)的诊断价值。方法以279例女性性早熟患儿为研究对象,其中CPP 175例、单纯乳房早发育(PT)104例,均行体格生长评价、骨龄测定以及基础LH、卵泡刺激素(FSH)检测和性激素激发试验等。采用受试者工作曲线(ROC)分析基础LH、FSH及其峰值对诊断CPP的意义,并分析基础LH与LH峰值的相关性。结果 CPP组的骨龄,基础LH、FSH,以及LH和FSH峰值,LH/FSH峰值之比均较PT组升高(P0.01)。以基础LH和LH峰值诊断效果较好。基础LH对骨龄7.0~9.0岁,9.0~11.0岁,11.0岁3个CPP亚组的诊断价值以11.0岁组的曲线下面积(AUC)最大。基础LH在0.45 IU/L时Youden指数最大,灵敏度为0.667、特异度为0.8;LH峰值在9.935 IU/L时Youden指数最大,灵敏度为0.748、特异度为1。基础LH与LH峰值成正相关(r=0.440、P0.01)。结论基础LH可作为诊断CPP的初筛指标,在不同骨龄阶段均有一定的诊断价值,并可作为疗效监测指标。
[Abstract]:Objective to evaluate the value of basic serum luteinizing hormone (LH) in the diagnosis of central precocious puberty (CPP) in women. Methods 279 cases of female precocious precocious puberty were studied, including 175 cases of CPP and 104 cases of simple breast development (PT). The physical growth evaluation, bone age measurement, basic LH, follicle stimulating hormone (FSH) and sex hormone stimulation test were performed. Using the subjects' work curve (ROC) to analyze the significance of basic LH, FSH and its peak value for the diagnosis of CPP, and to analyze the correlation between the basic LH and the peak value of LH. Results the bone age of the CPP group, the basic LH, FSH, and the LH and FSH peaks are all higher than those of the peak value of the LH/FSH. The diagnostic value of 1 years old, 11 year old and 3 CPP subgroups was the largest in the area under the curve of the 11 year old group (AUC). The Youden index of the base LH at 0.45 IU/L was the largest, the sensitivity was 0.667, the specificity was 0.8; the peak value of LH was 9.935 IU/L, the Youden index was the largest, the sensitivity was 0.748, the specificity was 1. base LH and LH peak was positive correlation (r=0.440, P0.01). It can be used as a screening index for diagnosing CPP. It has certain diagnostic value in different bone age stages and can be used as a monitoring index for curative effect.
【作者单位】：四川大学华西第二医院儿科;
【分类号】：R725.8

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