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东南大学附属中大医院住院患儿肺炎支原体感染与喘息相关性的回顾性研究

发布时间:2018-06-02 17:21

  本文选题:社区获得性肺炎 + 肺炎支原体肺炎 ; 参考:《东南大学》2015年硕士论文


【摘要】:目的:本文旨在总结中国东部地区一家三级医院中,儿童肺炎支原体肺炎(Mycoplasma Pneumoniae pneumonia, MPP)的主要临床表现及实验室检查特点;探讨该病的发生率及其与喘息的相关性;并探索肺炎支原体(Mycoplasma Pneumoniae, MP)感染与儿童哮喘的潜在关系。方法:本研究回顾性分析了2013年1月1日至2013年12月30日住院的3个月至15岁的社区获得性肺炎(community acquired pneumonia, CAP)患儿的临床资料。肺炎的诊断标准为具有发热和/或急性呼吸道症状(咳嗽、气促、呼吸困难等),以及胸部影像学检查发现新的浸润病灶。急性MP感染由临床表现和血清学阳性检查结果和/或咽拭子培养阳性决定。所有病例依此分为两组:MPP组和非MPP组。血液学检查包括:IgE和MP特异性的IgG、IgM。人口统计学资料包括年龄、性别。应用配对t检验或卡方检验对数据进行统计学分析。结果:咳嗽、喘息、咽痛这三个症状在两组之间差异具有统计学意义(P0.05,P0.05,P0.01)。与非MPP患儿相比,MPP组IgE上升(100IU/dl)的患儿更多,差异具有统计学意义(P0.01);发生喘息的患儿更多,差异具有统计学意义(P0.05)。结论:本研究证实喘息常常与MP感染所致的儿童CAP相关。类似的,IgE升高在MP阳性患儿更常见,表明体内存在过度的免疫反应,而喘息是免疫介导的气道高反应性所产生的,因此MP感染可能在儿童的特应性体质及哮喘发生中起着一定的作用。
[Abstract]:Objective: to summarize the main clinical manifestations and laboratory characteristics of Mycoplasma pneumoniae Pneumoniae pneumonia, MPP) in a tertiary hospital in eastern China, and to explore the incidence of Mycoplasma pneumoniae and its correlation with wheezing. To explore the potential relationship between Mycoplasma pneumoniae (MPI) infection and childhood asthma. Methods: the clinical data of patients with community acquired pneumonia (acquired pneumonia, CAP) from January 1, 2013 to December 30, 2013, aged from 3 months to 15 years, were retrospectively analyzed. The diagnostic criteria for pneumonia are fever and / or acute respiratory symptoms (cough, shortness of breath, dyspnea, etc.), as well as chest imaging findings of new invasive lesions. Acute MP infection is determined by clinical manifestations and seropositive results and / or pharyngeal swab culture. All cases were divided into two groups: MPP group and non-MPP group. Hematologic examination included the specific IgGG of IgE and MP IgM. Demographic data include age and sex. The data were statistically analyzed by paired t test or chi-square test. Results: the three symptoms of cough, wheezing and sore throat were significantly different between the two groups. Compared with the non-MPP group, there were more patients with 100 IUU / dll in MPP group, the difference was statistically significant (P0.01), and the incidence of wheezing was more (P0.05%) in MPP group than that in non-MPP group. Conclusion: this study confirms that wheezing is often associated with CAP in children with MP infection. Similar elevated IgE levels are more common in MP positive children, suggesting an excessive immune response in the body, while wheezing is caused by immune-mediated airway hyperresponsiveness. MP infection may play an important role in children's atopic constitution and asthma.
【学位授予单位】:东南大学
【学位级别】:硕士
【学位授予年份】:2015
【分类号】:R725.6

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1 亚达(Shakti NrisinghYadav);东南大学附属中大医院住院患儿肺炎支原体感染与喘息相关性的回顾性研究[D];东南大学;2015年



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