痰热清联合吸入用布地奈德对小儿支气管哮喘的治疗作用及对气道反应性和hs-CRP、降钙素原的影响

发布时间：2018-06-03 00:34

本文选题：布地奈德 + 痰热清　；参考：《中药材》2017年07期

【摘要】：目的:研究雾化吸入布地奈德和痰热清对支气管哮喘急性发作患儿的临床疗效及对哮喘患儿气道反应性、超敏C反应蛋白(hs-CRP)、降钙素原(PCT)的影响。方法:选取2015年1月~2016年10月在海口市妇幼保健院儿科就诊的112例支气管哮喘患儿随机分为观察组和对照组各56例,两组患儿均接受常规综合治疗,对照组患儿给予雾化吸入布地奈德治疗,对照组患儿给予雾化吸入布地奈德及静脉注射痰热清注射液,疗程为1周,比较两组患儿临床症状的持续时间及综合临床疗效,测定治疗前及治疗1周时两组患儿的气道反应性及血清hs-CRP和PCT水平。结果:(1)观察组显效率为91.07%,显著高于对照组(P0.05);(2)观察组患儿各临床症状(咳嗽、憋喘、肺部哮鸣音和肺部湿Up音)持续时间均较对照组显著缩短(P0.05);(3)治疗后观察组患儿Dmin、Cmin、SGrs及SGrs/Grs均较对照组显著升高(P0.05);(4)治疗后观察组患儿hs-CRP和PCT均较对照组显著降低(P0.05)。结论:雾化吸入布地奈德联合痰热清对急性发作期哮喘患儿具有较好的临床疗效,可迅速消除临床症状,降低患儿气道反应性,并降低血浆超敏C反应蛋白和降钙素原水平。
[Abstract]:Aim: to study the clinical effect of inhaled budesonide and Tanreqing on children with acute asthma and the effects on airway reactivity, hypersensitive C-reactive protein hs-CRP, procalcitonin (PCT) in children with asthma. Methods: 112 children with bronchial asthma from January 2015 to October 2016 were randomly divided into observation group (n = 56) and control group (n = 56). Children in the control group were treated with budesonide, and those in the control group were treated with budesonide and phlegm injection. The course of treatment was 1 week. The duration of clinical symptoms and the comprehensive clinical effect were compared between the two groups. Airway reactivity and serum hs-CRP and PCT levels were measured before treatment and 1 week after treatment. Results the effective rate of the observation group was 91.07, which was significantly higher than that of the control group (P 0.05). The duration of lung wheezing and lung wet up tone were significantly shorter than that of control group (P 0.05). After treatment, the hs-CRP and PCT of observation group were significantly lower than that of control group. Conclusion: inhaled budesonide combined with Tanreqing has a good clinical effect on children with acute asthma. It can quickly eliminate clinical symptoms, reduce airway reactivity, and reduce plasma hypersensitive C-reactive protein and procalcitonin levels.
【作者单位】：海口市妇幼保健院儿内科;
【分类号】：R725.6

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