2010-2015年重庆市某三甲儿童医院新生儿感染细菌的变迁及耐药性分析

发布时间：2018-06-04 04:55

本文选题：新生儿感染 + 细菌变迁　；参考：《中国感染与化疗杂志》2017年04期

【摘要】：目的了解2010-2015年重庆医科大学附属儿童医院所在地区新生儿感染细菌的变迁特征及耐药性,为临床合理使用抗菌药物和预防控制医院感染提供依据。方法分析该期间检出病原菌的构成和前几位病原菌对抗菌药物的耐药性,采用BD Phoenix 100仪器结合纸片扩散法进行药敏试验,按CLSI标准判断结果。结果 2010-2015年检出病原菌10 569株,其中革兰阴性菌8 540株,占80.8%;以肺炎克雷伯菌为主,其次是大肠埃希菌、鲍曼不动杆菌、阴沟肠杆菌、铜绿假单胞菌,检出率分别为29.3%、16.7%、9.9%、8.6%、3.3%。革兰阳性菌1 490株,占14.1%;以金黄色葡萄球菌为主,其次是表皮葡萄球菌、溶血葡萄球菌,检出率分别为7.8%、2.2%、1.8%。肠杆菌科细菌对亚胺培南、美罗培南耐药率10%,其次是铜绿假单胞菌10%,而鲍曼不动杆菌耐药率均20%;碳青霉烯类耐药的肺炎克雷伯菌和大肠埃希菌比例分别接近8.4%和2.9%。未检出耐万古霉素、替考拉宁、利奈唑胺的革兰阳性菌。结论该医院所在地区新生患儿感染细菌以肺炎克雷伯菌居多,呼吸道感染最为常见,鲍曼不动杆菌检出率呈逐年上升趋势,其余细菌未见趋势性变化。耐碳青霉烯类肠杆菌科细菌较多。
[Abstract]:Objective to investigate the changes and drug resistance of neonatal infection bacteria in children's hospital affiliated to Chongqing Medical University from 2010 to 2015 so as to provide evidence for rational use of antimicrobial agents and prevention and control of nosocomial infection. Methods the composition of the pathogens and the drug resistance of the first few pathogens to antimicrobial agents were analyzed. The susceptibility test was carried out by BD Phoenix 100 instrument combined with disk diffusion method, and the results were judged by CLSI standard. Results 10 569 strains of pathogenic bacteria were detected from 2010 to 2015, of which 8 540 were gram-negative bacteria (80.8%), followed by Escherichia coli, Acinetobacter baumannii, Enterobacter cloacae, Pseudomonas aeruginosa, and the positive rate was 29.30.16.79.99.98.63.3B. the main pathogens were Klebsiella pneumoniae, followed by Escherichia coli, Acinetobacter baumannii, Enterobacter cloacae and Pseudomonas aeruginosa. There were 1 490 Gram-positive bacteria (14.1%), followed by Staphylococcus aureus, Staphylococcus epidermidis and Staphylococcus haemolyticus, the detectable rate was 7.82.2and 1.8cm, respectively. The resistance rate of Enterobacteriaceae to imipenem and meropenem was 10%, followed by Pseudomonas aeruginosa 10, and Acinetobacter baumannii 20%, the rates of carbapenem resistant Klebsiella pneumoniae and Escherichia coli were nearly 8.4% and 2.9%, respectively. No vancomycin resistant, teicoplanin and linazolamide resistant gram-positive bacteria were detected. Conclusion Klebsiella pneumoniae is the most common infection bacteria in newborn children in this hospital. The detection rate of Acinetobacter baumannii is increasing year by year. There are more enterobacteriaceae bacteria resistant to carbapenem.
【作者单位】：重庆医科大学附属儿童医院检验科儿童发育疾病研究教育部重点实验室儿科学重庆市重点实验室重庆市儿童发育重大疾病诊治与预防国际科技合作基地;
【分类号】：R722.13

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