2015年～2016年石家庄地区儿童病毒性脑炎病原学研究

发布时间：2018-06-05 06:47

本文选题：病毒性脑炎 + 病原　；参考：《病毒学报》2017年02期

【摘要】：为了解石家庄地区儿童病毒性脑炎病原学特点,同时研究病原学资料与临床资料之间的联系。本研究采用实验室全自动工作站,结合实时荧光定量PCR方法检测2015年10月~2016年9月河北省儿童医院神经内科收治的诊断为病毒性脑炎患儿的脑脊液样本,并结合临床资料进行分析。159例病毒性脑炎患儿中66例(41.5%)检出病毒阳性,肠道病毒58例,EB病毒3例,人疱疹病毒6型1例,4例为合并感染,分别为肠道病毒合并EB病毒3例,肠道病毒合并人疱疹病毒6型1例。肠道病毒是石家庄地区儿童病毒性脑炎最常见的病原。运用SPSS21.0统计分析软件对实验数据进行统计学分析。肠道病毒脑炎于炎热季节高发。不同病原病毒性脑炎患儿的年龄分布无显著差异。不同病原病毒性脑炎患儿的脑脊液样本采集时间分布无显著差异。不同病原病毒性脑炎患儿的临床症状和体征、MRI结果、EEG结果无显著差异。
[Abstract]:To understand the etiological characteristics of viral encephalitis in children in Shijiazhuang area and to study the relationship between etiological data and clinical data. In this study, the cerebrospinal fluid (CSF) samples of children diagnosed as viral encephalitis were detected by laboratory automatic workstation and real-time fluorescence quantitative PCR method from October 2015 to September 2016 in Department of Neurology, Hebei Children's Hospital. Combined with clinical data, 66 cases of viral encephalitis were found to be positive in 66 cases. 3 cases were enterovirus, 3 cases were enterovirus, 4 cases were combined infection of human herpesvirus 6, 3 cases were enterovirus combined with EB virus, 3 cases were enterovirus combined with EB virus, respectively. One case of enterovirus combined with human herpesvirus 6. Enterovirus is the most common pathogen of viral encephalitis in children in Shijiazhuang area. SPSS21.0 statistical analysis software was used to analyze the experimental data. Enterovirus encephalitis is high in the hot season. There was no significant difference in age distribution among children with viral encephalitis. There was no significant difference in the time distribution of cerebrospinal fluid (CSF) collection among children with viral encephalitis. The clinical symptoms and signs of different pathogenic viral encephalitis and EEG results were not significantly different.
【作者单位】：中国疾病预防控制中心病毒病预防控制所;河北省儿童医院神经内科;
【基金】：国家重点研发计划课题(项目号:2016YFC120090),题目:媒介防控与应急处置技术与产品研究
【分类号】：R725.1

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