早期应用神经保护因子对先天性巨细胞病毒感染新生儿的听力保护作用

发布时间：2018-06-08 17:44

  本文选题：神经保护因子 + 巨细胞病毒感染　； 参考：《广东医学》2017年08期

【摘要】：目的探讨神经保护因子早期干预对先天性巨细胞病毒感染新生儿听力损伤的保护作用。方法48例先天性巨细胞病毒感染新生儿分为两组,甲组23例用常规治疗(更昔洛韦),乙组25例在常规治疗基础上增加神经保护因子神经节苷酯,分别收集生后3、42 d听力筛查情况及3个月和6个月脑干听觉诱发电位(ABR)检查结果,分析两种治疗在听力保护方面的疗效。结果乙组患儿在42 d筛查不通过率低于甲组,3个月及6个月ABR检查V波阈值平均值低于甲组(P0.05)。结论神经保护因子对先天性巨细胞病毒感染患儿的听觉系统有保护作用,可一定程度上降低此类患儿听力的损伤程度。
[Abstract]:Objective to investigate the protective effect of early intervention of neuroprotective factor on hearing loss in neonates with congenital cytomegalovirus infection. Methods 48 neonates with congenital cytomegalovirus infection were divided into two groups. Group A (23 cases) received routine treatment (ganciclovir), group B (25 cases) increased the neuroprotective factor ganglioside ester on the basis of routine treatment. The results of hearing screening and brainstem auditory evoked potential (ABR) at 3 and 6 months after birth were collected, and the effects of the two treatments on hearing protection were analyzed. Results the screening failure rate of group B was lower than that of group A at 42 days, and the threshold value of V wave in ABR at 3 and 6 months was lower than that in group A (P 0.05). Conclusion Neuroprotective factor has protective effect on hearing system of children with congenital cytomegalovirus infection, and can reduce hearing impairment to some extent in children with congenital cytomegalovirus infection.
【作者单位】： 西安医学院第一附属医院儿科;
【分类号】：R722.13
，

本文编号：1996647