中西医结合治疗川崎病疗效评价

发布时间：2018-06-14 11:55

本文选题：自拟中药组方 + 丙种球蛋白　；参考：《中华中医药学刊》2017年05期

【摘要】：目的:分析与探讨采用自拟中药组方、阿司匹林以及丙种球蛋白联合治疗川崎病(MCLS)疗效及评价。方法:将临床确诊后进行治疗的122例MCLS病患选择为临床研究病例,根据就诊顺序编号并将单双号分成两组。对照组(单号)61例给予阿司匹林和丙种球蛋白进行治疗,试验组(双号)61例在对照组基础上联合自拟中药组方治疗。比较病患治疗效果、症状消失时间、炎症因子水平及冠状动脉病变情况。结果:试验组患儿冠状动脉病变发生率4.92%、退热时间(2.76±1.02)d、淋巴结肿大消失时间(7.49±1.55)d、皮疹消失时间(4.79±0.78)d、治疗总有效率93.44%、IL-6(17.21±6.01)ng/L、IL-8(180.68±22.08)ng/L、TNF-α(33.99±9.32)ng/L均明显优于对照组冠状动脉病变发生率18.03%、退热时间(3.54±1.33)d、淋巴结肿大消失时间(9.88±2.16)d、皮疹消失时间(6.53±0.47)d、治疗总有效率72.13%、IL-6(30.18±7.14)ng/L、IL-8(240.88±34.85)ng/L、TNF-α(54.18±21.41)ng/L,统计学上有意义(P0.05)。结论:MCLS病患采用阿司匹林、丙种球蛋白以及自拟中药组方联合治疗,病患各种症状消失时间较快,炎症因子水平明显降低,提高临床治疗效果,有效预防冠状动脉病变,满足患儿及家属期望值。
[Abstract]:Objective: to analyze and evaluate the efficacy and evaluation of Chinese medicine prescription, aspirin and gamma globulin in the treatment of Kawasaki disease. Methods: 122 patients with MCLS were selected as clinical study cases and divided into two groups. The control group (61 cases) were treated with aspirin and gamma globulin, and the experimental group (61 cases) were treated with traditional Chinese medicine prescription on the basis of the control group. The therapeutic efficacy, duration of symptom disappearance, inflammatory factor level, and coronary artery disease were compared. Results: the incidence of coronary artery disease, antipyretic time (2.76 卤1.02d), lymph node enlargement (7.49 卤1.55g / d) and rash disappearance time (4.79 卤0.78d) were significantly higher in the trial group than those in the control group. The total effective rate of the treatment was 93.444.44 卤6.01 ng / L IL-8180.68 卤22.08 ng / L TNF- 伪 33.99 卤9.32 ng-1 / L, respectively, and the antifebrile time was 3.54 卤1.33 d. The disappearance time of lymph node enlargement was 9.88 卤2.16 days, the time of exanthema disappearance was 6.53 卤0.47 days, the total effective rate of treatment was 30.18 卤7.14 ng / L of IL-6 and 30.18 卤7.14 ng / L of IL-8 + IL-80.88 卤34.85 ng / L of TNF- 伪 54.18 卤21.41 ng / L of TNF- 伪, statistically significant (P 0.05). Conclusion the combined therapy of aspirin, gamma globulin and traditional Chinese medicine can decrease the level of inflammatory cytokines, improve the clinical effect and prevent coronary artery disease. To meet the expectations of the children and their families.
【作者单位】：河北大学附属医院儿科;保定市第一医院;保定市第二医院;保定市第一中心医院;
【基金】：保定市科技局项目(16ZF034)
【分类号】：R725.4

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