血清维生素D水平与过敏性紫癜患儿病情及治疗的关系

发布时间：2018-06-14 15:24

本文选题：过敏性紫癜 + 羟基维生素D_　；参考：《中国当代儿科杂志》2017年07期

【摘要】：目的探讨血清维生素D水平与过敏性紫癜(HSP)患儿病情及治疗的关系。方法选取2015年1~12月第1次诊断为HSP的患儿50例为HSP组,以49例健康儿童作为健康对照组。空腹采集两组儿童血清,采用ELISA法检测血清25羟基维生素D_3[25-(OH)D_3]水平。根据25-(OH)D_3检测结果将HSP患儿进一步分为维生素D正常组(20 ng/m L)(n=9)、不足组(15 ng/m L~20 ng/m L)(n=15)、缺乏组(≤15 ng/m L)(n=25)、严重缺乏组(≤5 ng/m L)(n=1)。收集HSP患儿的一般资料、临床表现、激素治疗情况、入院前病程及住院天数进行分析比较。结果 HSP组患儿血清25-(OH)D_3水平(16±6 ng/m L)低于健康对照组(29±5 ng/m L)(P0.01)。与正常组+不足组患儿[25-(OH)D_315 ng/m L]相比,缺乏组+严重缺乏组患儿[25-(OH)D_3≤15 ng/m L]肾脏受累发生率、激素使用率均增高(P0.05),中位住院天数延长(P0.05),但入院前病程差异无统计学意义(P0.05)。结论 HSP患儿血清25-(OH)D_3水平低,低血清25-(OH)D_3水平HSP患儿肾脏受累风险及激素使用率增高,住院时间延长。但补充维生素D对HSP有无治疗作用,能否缩短HSP患儿病程,改善远期预后,仍有待进一步研究。
[Abstract]:Objective to investigate the relationship between serum vitamin D level and the condition and treatment of children with anaphylactoid purpura (HSP). Methods 50 children diagnosed as HSP in 2015 1~12 month were HSP group and 49 healthy children were used as healthy control group. Two groups of children's serum were collected on empty stomach and serum 25 hydroxyvitamin D_3[25- (OH) D_3] level was measured by ELISA method. According to the results of 25- (OH) D_3, the children of HSP were further divided into the normal group of vitamin D (20 ng/m L) (n=9), the deficiency group (15 ng/m L~20 ng/m L), the lack group (less than 15), and the severe deficiency group (less than 5). Results the serum level of 25- (OH) D_3 (16 + 6 ng/m L) in the HSP group was lower than that in the healthy control group (29 + 5 ng/m L) (P0.01). But there was no statistical significance (P0.05) before admission. Conclusion the serum 25- (OH) D_3 level of children with HSP was low, and the risk of kidney involvement and hormone use rate increased and the time of hospitalization was prolonged in children with low serum 25- (OH) D_3 level, but vitamin D supplementation had no therapeutic effect on HSP. Research.
【作者单位】：贵州省人民医院儿科;
【基金】：[基金项目]贵阳市科技计划项目筑科合同[20141001]51号
【分类号】：R725.5

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