小剂量化疗与手术治疗儿童孤立性骨嗜酸性肉芽肿的效果比较

发布时间：2018-06-19 13:16

  本文选题：嗜酸性肉芽肿 + 单发　； 参考：《中山大学学报(医学科学版)》2017年05期

【摘要】：【目的】探讨小剂量化疗、手术及手术加术后辅助小剂量化疗这三种不同的方法在儿童孤立性骨嗜酸性肉芽肿(SBL-EG)治疗上的有效性及可行性。【方法】回顾性分析了149例SBL-EG的儿童患者,其中86例接受小剂量化疗,33例行手术治疗,30例接受手术及术后辅助小剂量化疗。比较三组患者的住院时间、症状缓解时间、恢复时间、治疗费用、并发症及无复发生存时间(RFS)。【结果】小剂量化疗组的住院时间、症状缓解时间、恢复时间及治疗费用均低于手术或手术加化疗组(P0.05),而手术组与手术加化疗组在上述4个方面的对比均无明显统计学差异(P0.05)。小剂量化疗组及手术加化疗组中化疗药物相关的副作用包括恶心(8.62%),转氨酶升高(7.76%),轻度脱发(4.31%),抵抗力下降(21.55%),生长发育迟滞(10.34%)及满月脸(7.76%)。小剂量化疗组及手术加化疗组的RFS(147月及126月)明显长于手术组(114月)(P=0.005及0.019)。然而,小剂量化疗组及手术加化疗组的RFS差异无统计学意义(P=0.732)。【结论】在SBL-EG的儿童患者治疗上,相对于手术或手术加化疗而言,小剂量化疗是一种创伤小、恢复快、经济、安全有效的方法。
[Abstract]:[objective] to study the low dose chemotherapy, The efficacy and feasibility of three different methods of adjuvant small dose chemotherapy in children with isolated bone eosinophilic granulomatosis (SBL-EGG) were studied. [methods] 149 cases of children with SBL-EG were retrospectively analyzed. Among them, 86 cases received small dose chemotherapy and 33 cases received surgical treatment and 30 cases received surgery and postoperative adjuvant small dose chemotherapy. The hospitalization time, symptom remission time, recovery time, treatment cost, complication and survival time without recurrence were compared among the three groups. [results] the hospitalization time, symptom remission time of the small dose chemotherapy group were compared. The recovery time and the cost of treatment were lower than those of the operation or operation plus chemotherapy group (P 0.05), but there was no significant difference between the operation group and the operation plus chemotherapy group in the above four aspects. The side effects of chemotherapy-related drugs in the low dose chemotherapy group and the operation plus chemotherapy group included nausea 8.62am, aminotransferase increased 7.76g, mild alopecia 4.31%, resistance decreased 21.55%, growth retardation 10.34%) and full moon 7.76g. RFSs in the small dose chemotherapy group and the operation plus chemotherapy group were significantly longer than those in the operation group (14.7 months and 12.6 months). However, there was no significant difference in RFS between the small dose chemotherapy group and the operation plus chemotherapy group. [conclusion] in the treatment of children with SBL-EG, compared with surgery or surgery plus chemotherapy, small dose chemotherapy is a kind of small trauma, quick recovery and economic. A safe and effective method.
【作者单位】： 中山大学附属第一医院骨肿瘤科;华南肿瘤学国家重点实验室//中山大学肿瘤防治中心;
【基金】：国家自然科学基金面上项目(81572638) 广东省自然科学基金(S2013010015384,2014A030313219)
【分类号】：R726.8
，

本文编号：2040013