紫癜性肾炎患儿肾脏IgG亚型分布及意义

发布时间：2018-06-19 14:27

本文选题：紫癜性肾炎 + IgG亚型　；参考：《河南医学研究》2015年01期

【摘要】：目的探讨紫癜性肾炎(HSPN)肾脏Ig G亚型沉积特点及其临床意义。方法回顾性分析2012年12月至2014年5月郑州大学第一附属医院住院治疗并行肾脏穿刺活检术的88例HSPN患儿资料,对其病理类型及Ig G亚型进行统计,分为Ig G沉积(+)A组和Ig G沉积(-)B组,比较两组临床及病理差异。结果依据肾脏病理将其分为两组,其中Ig G(+)共26例为A组,占30%;Ig G(-)共62例为B组,占70%。A、B组发病年龄、性别、起病时间、尿蛋白定量及肾脏病理分级差异无统计学意义(P0.05);A组伴有感染及关节症状者所占比例明显高于B组,差异均有统计学意义(P0.05)。A组行Ig G亚型检测12例Ig G1(+),1例Ig G2(+),1例Ig G3(+),3例Ig G1、Ig G2(+),1例Ig G1、Ig G4(+),1例Ig G2、Ig G4(+),4例Ig G1、Ig G2、Ig G3(+),3例Ig G亚型全阴,Ig G4亚型沉积的阳性率最低。结论 HSPN患儿Ig G(+)除典型紫癜表现外,常伴有感染、关节症状;免疫荧光亚型分析以Ig G1沉积为主,Ig G2、Ig G3次之,Ig G4沉积最少,在免疫复合物Ig G介导的肾损害中,Ig G1可能占主导作用。
[Abstract]:Objective to investigate the deposition characteristics and clinical significance of Ig G subtype in the kidney of Henoch-Schonlein purpura nephritis (HSPN). Methods from December 2012 to May 2014, 88 children with HSPN who were hospitalized in the first affiliated Hospital of Zhengzhou University and underwent renal biopsy were analyzed retrospectively. The pathological types and Ig G subtypes of HSPN were statistically analyzed. The patients were divided into two groups: group A and group B. The clinical and pathological differences were compared between the two groups. Results according to renal pathology, it was divided into two groups: group A (26 cases) and group B (62 cases). There was no significant difference in urinary protein quantification and renal pathological grade. The proportion of patients with infection and joint symptoms in group A was significantly higher than that in group B. The positive rate of IgG subtype was lowest in 12 cases of Ig G1 (1 case of Ig G2) (1 case of Ig G3) (3 cases of Ig G1 + Ig G2) (1 case of Ig G1 + Ig G4) (1 case of Ig G2 + Ig G4) (4 cases of Ig G1 + Ig G2Ig G3) (3 cases of Ig G subtype Ig G 4). Conclusion in HSPN children, in addition to the typical manifestations of purpura, Ig G3 is often associated with infection and joint symptoms, immunofluorescence subtypes are mainly Ig G 1 deposition, Ig G 2 + Ig G 3 is the second, and Ig G 4 is the least. Ig G 1 may play a dominant role in renal damage mediated by immune complex IgG.
【作者单位】：郑州大学第一附属医院小儿内科;
【分类号】：R726.9

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