低磷抗维生素D性佝偻病诊治进展

发布时间：2018-06-21 15:40

本文选题：低磷抗维生素D性佝偻病 + -(OH)_D_　；参考：《中国实用儿科杂志》2017年09期

【摘要】：低磷抗维生素D性佝偻病是一组以肾脏磷排泄增多、血磷降低为核心特征的代谢性骨病。机体磷代谢是一个复杂的反馈调节网络,其中甲状旁腺素(PTH)、成纤维细胞生长因子23(FGF23)以及1,25-(OH)2D3是最为关键的调控因子。随着对磷代谢及其发病机制认识的深入,低磷抗维生素D性佝偻病的诊断与治疗取得了新的进展。该文在阐述机体磷代谢调控机制的基础上,介绍低磷性佝偻病常见类型的发病机制及临床表现,总结低磷性佝偻病诊断方法并阐述最新治疗进展。
[Abstract]:Low phosphorus resistant vitamin D rickets is a metabolic bone disease characterized by increased phosphorus excretion in the kidney and decreased blood phosphorus. Phosphorus metabolism is a complex feedback regulatory network in which PTH, fibroblast growth factor 23 (FGF23) and OH2D3 are the most important regulatory factors. With the deep understanding of phosphorus metabolism and its pathogenesis, new progress has been made in the diagnosis and treatment of vitamin D rickets with low phosphorus. On the basis of explaining the regulation mechanism of phosphorus metabolism, this paper introduces the pathogenesis and clinical manifestations of low phosphorus rickets, summarizes the diagnostic methods of low phosphorus rickets and describes the latest treatment progress.
【作者单位】：华中科技大学同济医学院附属同济医院儿科;
【分类号】：R723.2

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