术前化疗对儿童肾母细胞瘤疗效的Meta分析

发布时间：2018-06-22 13:16

本文选题：肾母细胞瘤 + 术前化疗　；参考：《重庆医科大学》2012年硕士论文

【摘要】：目的：评估术前化疗对儿童肾母细胞瘤肿瘤缩小率、肿瘤全切率及术后无瘤生存率影响，为进一步提高临床治疗效果及研究水平提供参考。方法：根据制定好的检索策略，计算机检索PubMed，Cochrane（2011年第3期），OVID（包括EMbase和Biosis previews数据库），VIP，CNKI，Wang Fang Data，由2名评价员按纳入排除标准独立选择文献、提取数据并交叉核对，依据Cochrane handbook5.0.0推荐的4条随机对照试验质量评价标准评价纳入研究的方法学质量，并采用Stata11软件进行统计分析。结果：最终纳入30个研究,研究存在中度或高度偏倚的可能性。Meta分析结果显示，术前化疗加手术治疗与单纯手术比较，能提高肾母细胞瘤肿瘤缩小率、肿瘤全切率和术后无瘤生存率，两组差异有统计学意义[分别为OR=37.28，95%CI(20.18，68.81)，P=0.0000；OR=5.923，95%CI(3.14，10.95)，，P=0.000；OR=2.03，95%CI(1.58，2.60)，P=0.000]。结论：术前化疗能提高儿童肾母细胞瘤肿瘤缩小率、肿瘤全切率和可能提高术后无瘤生存率。
[Abstract]:Objective: to evaluate the effect of preoperative chemotherapy on tumor reduction rate, total tumor resection rate and tumor free survival rate in children with nephroblastoma. Methods: according to the established search strategy, the online search was performed on PubMedan Cochrane (issue 3, 2011), which included Embase and Biosis previews databases. Two evaluators independently selected the literature according to the exclusion criteria, extracted the data and cross-checked the data. The methodological quality of four randomized controlled trials recommended by Cochrane handbook5.0.0 was evaluated and statistically analyzed by Stata11 software. Results: the possibility of moderate or high bias was found in 30 studies. Meta-analysis showed that preoperative chemotherapy plus surgical treatment could increase the tumor size of nephroblastoma compared with surgery alone. The total tumor resection rate and the postoperative tumor-free survival rate were significantly different between the two groups [CI (20.18 卤68.81) P 0.0000] 5.92395 CI (3.14 卤10.95) P 0.000 OR 2.03C _ (95) CI (1.582.60) P0. 000). Conclusion: preoperative chemotherapy can improve tumor reduction rate, total tumor resection rate and tumor free survival rate of children with nephroblastoma.
【学位授予单位】：重庆医科大学
【学位级别】：硕士
【学位授予年份】：2012
【分类号】：R737.11

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