儿童原发性免疫性血小板减少症骨髓巨核细胞数临床意义

发布时间：2018-06-23 03:06

本文选题：免疫性血小板减少症 + 骨髓巨核细胞　；参考：《中国实用儿科杂志》2017年01期

【摘要】：目的分析原发性免疫性血小板减少症(ITP)患儿的骨髓巨核细胞数特点及其与疗效的关系。方法收集2005年1月至2012年1月在四川大学华西第二医院住院行骨髓检查的642例原发性ITP患儿资料,给予激素冲击治疗和(或)静脉注射免疫球蛋白治疗,疗效判定依据血小板计数高低和出血症状改善分为:完全有效、有效、无效。患儿在使用激素治疗前行骨髓穿刺检查以排除继发性血小板减少性疾病。应用SPSS 12.0软件对其临床资料进行回顾性分析。结果巨核细胞正常组(64例)中位年龄小于巨核细胞增多组(569例),差异有统计学意义(Z=-2.006,P=0.045)。巨核细胞正常组入院时血小板中位数高于巨核细胞增多组,差异有统计学意义(Z=-2.354,P=0.019)。两组不同分型间比例差异无统计学意义(χ2=1.422,P=0.491)。巨核细胞正常组经治疗后有效率低于巨核细胞增多组,差异有统计学意义(χ~2=13.927,P0.001)。结论原发性ITP患儿入院时骨髓巨核细胞数正常者血小板数高于骨髓巨核细胞增多者。治疗前骨髓巨核细胞数有助于判定疗效,但与患儿是否发展为慢性ITP无确切关系。
[Abstract]:Objective to analyze the characteristics of bone marrow megakaryocytes in children with primary immune thrombocytopenia (ITP) and their relationship with the curative effect. Methods 642 children with primary ITP were collected from January 2005 to January 2012 at the second hospital in Western Huaxi Second Hospital of Sichuan University, and the shock therapy and / or intravenous immunoglobulin were given. Treatment, the curative effect was determined according to the platelet count and bleeding symptoms to be improved: completely effective, effective, ineffective. The children were treated with bone marrow puncture before using hormone therapy to eliminate secondary thrombocytopenia. SPSS 12 software was used to review the clinical data. Results the median year of megakaryocyte (64 cases) was in the normal group. The age was less than the megakaryocytosis group (569 cases), the difference was statistically significant (Z=-2.006, P=0.045). The median of platelets in the normal megakaryocyte group was higher than that of the megakaryocytosis group, the difference was statistically significant (Z=-2.354, P=0.019). There was no statistical difference between the two groups (x 2=1.422, P=0.491). The normal group of megakaryocyte was treated by the normal group The effective rate was lower than the megakaryocytosis group, the difference was statistically significant (x ~2=13.927, P0.001). Conclusion the number of platelets in the patients with normal bone marrow megakaryocyte at admission is higher than that of bone marrow megakaryocytosis. The number of megakaryocytes before treatment is helpful to determine the therapeutic effect, but it is not closely related to the development of chronic ITP in children with chronic ITP. Department.
【作者单位】：四川大学华西第二医院儿童血液肿瘤科;西南医科大学附属医院儿科;成都市妇女儿童中心医院心脏内科;
【分类号】：R725.5

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