沈阳市2006—2010年大气污染与先天性心脏病病例对照研究

发布时间：2018-06-23 21:21

本文选题：大气污染 + 先天性心脏病　；参考：《中国公共卫生》2017年08期

【摘要】：目的探讨大气污染与出生缺陷即先天性心脏病(以下简称先心病)之间是否具有相关性。方法以妊娠期间居住于沈阳市、末次月经位于2006年1月1日—2010年12月31日且分娩先心病缺陷患儿的孕产妇共计842例为研究对象,利用病例对照研究分析妊娠妇女在妊娠前后暴露于大气污染物中与分娩先心病患儿之间的关系。结果沈阳市属中国大气污染较为严重的地区,每年的1—3月、11、12月是各污染物浓度均较高的时期,其中SO_2浓度最高时达到145.9μg/m~3,NO_2为541.4μg/m~3,PM10为163.6μg/m~3,每年的7月是SO_2、NO_2浓度较低的时期,SO_2为22μg/m~3,NO_2为27.2μg/m~3,PM10浓度最低月份在8月,为90.6μg/m~3,每月间污染物浓度差异有统计学意义。分娩先心病患儿孕妇在妊娠前2、3个月的SO_2暴露均值高于对照组,在妊娠第2、3个月的NO_2暴露均值高于对照组,妊娠前1、2、3个月、妊娠第1、2、3个月的所在地区PM10平均暴露浓度均高于对照组,且差异有统计学意义。结论妊娠妇女孕前3个月及妊娠早期应避免暴露于大气污染物浓度较高的地区,因其可能会诱发胎儿先心病的发生。
[Abstract]:Objective to investigate the relationship between air pollution and congenital heart disease (CHD). Methods A total of 842 pregnant women who lived in Shenyang during pregnancy and whose last menstruation was from January 1, 2006 to December 31, 2010, and who had congenital heart disease defects, were studied. Case-control study was used to analyze the relationship between exposure to air pollutants before and after pregnancy and children with congenital heart disease. Results Shenyang is a serious area of air pollution in China. The concentration of each pollutant is higher in December than in January to January each year. Among them, the highest concentration of SO2 is 145.9 渭 g / m ~ (3) no _ 2 = 541.4 渭 g / m ~ (-1) PM10 = 163.6 渭 g / m ~ (-1), and every year July is a period when so _ 2s _ (No2) is 22 渭 g 路m ~ (3) / min ~ (-1). The lowest month of the concentration of PM10 is 27.2 渭 g / m ~ (3) / min ~ (-1), which is 90.6 渭 g / m ~ (-3) in August, and there is a statistically significant difference in the concentration of pollutants between months. The mean value of SO2 exposure in pregnant women with congenital heart disease was higher than that in the control group at 2 and 3 months before pregnancy, and the mean value of No2 exposure in the 2nd and 3rd month of pregnancy was higher than that in the control group. The mean exposure concentration of PM10 in the first and third month of pregnancy was higher than that in the control group, and the difference was statistically significant. Conclusion three months before pregnancy and early pregnancy, women should avoid exposure to high concentration of atmospheric pollutants, which may induce fetal congenital heart disease.
【作者单位】：沈阳市妇幼保健院科教科;沈阳理工大学环境与化学工程学院;辽宁省环境监测实验中心;
【基金】：辽宁省科学技术计划项目(2015225025) 辽宁省科学事业公益研究基金项目(201500100) 沈阳市科学技术计划项目(F15-139-9-09) 辽宁省沈阳市卫计委青年科研项目(沈卫办[2015]479号)
【分类号】：R12;R725.4

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