新生儿真菌性败血症医院感染现状及危险因素分析

发布时间：2018-06-26 23:11

本文选题：新生儿 + 真菌性败血症　；参考：《现代预防医学》2017年05期

【摘要】：目的探讨新生儿重症监护病房(NICU)真菌性败血症的医院感染发病率、病原菌及危险因素,以针对性的制定新生儿真菌性败血症感染防控策略。方法对2015年1月至2016年6月郑州大学第一附属医院NICU收治的6962名患儿进行回顾性研究,分析真菌性败血症医院感染现状;并采用多因素Logistic回归探讨真菌性败血症医院感染的相关危险因素。结果 NICU真菌性败血症医院感染率为0.42%;血培养检出真菌29例,主要检出菌为白假丝酵母菌(37.93%),其次为菌膜假丝酵母菌(20.69%);单因素Logistic回归分析显示,早产儿、住院时间、抗菌药使用时间、抗菌药使用种类、极低出生体重儿、坏死性小肠结肠炎、中心静脉置管时间及呼吸机使用时间,与真菌性败血症的发生呈正相关。多因素Logistic回归分析表明,真菌性败血症的独立危险因素主要有早产儿(OR=5.975)和极低出生体重(OR=1.140)。结论本院NICU真菌性败血症医院感染率接近全国水平;早产儿和极低出生体重儿是NICU真菌性败血症发生的高危人群。
[Abstract]:Objective to investigate the nosocomial infection rate, pathogenic bacteria and risk factors of fungal septicemia in neonatal intensive care unit (NICU). Methods from January 2015 to June 2016, a retrospective study was conducted on 6962 children in the ICU of the first affiliated Hospital of Zhengzhou University, and the nosocomial infection status of fungal septicemia was analyzed. The risk factors of nosocomial infection of fungal septicemia were analyzed by multivariate logistic regression. Results the nosocomial infection rate of fungal septicemia was 0.42% in NICU, 29 cases were detected by blood culture, the main bacteria were Candida albicans (37.93%), the next was Candida cerevisiae (20.69%). The time of use of antibiotics, kinds of antibiotics, very low birth weight infants, necrotic enterocolitis, central venous catheterization and ventilator use time were positively correlated with the occurrence of fungal septicemia. Multivariate logistic regression analysis showed that the main independent risk factors of fungal septicemia were premature infants (OR5.975) and very low birth weight (OR1.140). Conclusion the nosocomial infection rate of fungal septicemia in NICU is close to the national level, premature infants and very low birth weight infants are the high risk population of fungal septicemia in NICU.
【作者单位】：郑州大学第一附属医院感染管理科;
【基金】：河南省科技攻关计划项目(162102310155)
【分类号】：R722.131

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