凉血健脾法对过敏性紫癜患儿血清LTB4、VEGF的影响

发布时间：2018-07-05 00:22

本文选题：过敏性紫癜 + 凉血健脾法　；参考：《福建中医药大学》2012年硕士论文

【摘要】：目的：观察对比西药常规治疗与加用凉血健脾中药治疗过敏性紫癜(Henoch-Schonlein purpura, HSP)患儿的临床疗效,及加入凉血健脾中药后对HSP患儿血清白三烯B4(Leukotriene B4, LTB4)、血管内皮生长因子(Vascular endothelial growth factor,VEGF)的影响,探讨凉血健脾法治疗HSP的临床疗效及机制。方法：选择符合入选标准的HSP患儿60例、健康同龄儿童30例(为同期于福建省立医院儿科门诊体检的健康儿童)。将HSP患儿随机分为西药组30例(采用西药常规治疗)和中西药组30例(加用凉血健脾中药治疗),分别观察两组临床疗效、临床症状改善时间、复发率。同时分别收集两组患儿治疗前后的血液,离心取血清后冷冻保存,用酶联免疫吸附法(ELISA)检测血清中LTB4、VEGF水平。对比两组治疗前后患儿血清LTB4、VEGF水平的差异,同时与健康同龄儿相比较。结果：①加用凉血健脾中药治疗的中西药组30例HSP患儿总显效率86.67%,优于常规西药治疗对照组63.33%(P=0.036)。②中西药治疗组总复发率9.99%,低于西药对照组16.66%(P=0.029)。③中西药治疗组临床症状(皮疹、关节痛、便血)改善起效时间分别为(6.73-±-3.40、3.24±1.64、1.88±0.83)天,明显短于西药对照组(9.43±3.95、3.29±1.20、4.71±-2.69)天,P均0.05。④中西药治疗组治疗后血清LTB4、VEGF水平低于西药常规治疗组(P均0.05),差异显著。结论：凉血健脾法治疗HSP患儿疗效显著,可抑制HSP患儿血清LTB4、VEGF水平,有一定的抗炎、保护内皮细胞作用,而达到辅助治疗HSP的疗效。
[Abstract]:Objective: To observe and compare the clinical efficacy of traditional western medicine and traditional Chinese medicine with cold blood and invigorating spleen for Henoch-Schonlein purpura (HSP), and the effect of adding cold blood and invigorating spleen on serum leukotriene B4 (Leukotriene B4, LTB4) and vascular endothelial Naga Innoko (Vascular endothelial growth factor) in children with HSP. Objective to investigate the clinical efficacy and mechanism of cooling blood and invigorating spleen in treating HSP.
Methods: 60 children with HSP and 30 healthy children of the same age were selected. The children were randomly divided into 30 cases of Western medicine group (30 cases of Western Medicine) and 30 cases of Chinese and Western Medicine (traditional Chinese medicine treatment). The clinical effects and clinical symptoms of the two groups were observed and the clinical symptoms were observed. At the same time, the blood of two groups of children before and after treatment were collected, and the serum levels of LTB4 and VEGF were detected by enzyme linked immunosorbent assay (ELISA). The difference of serum LTB4 and VEGF levels between the two groups before and after treatment was compared with those of the same age children.
Results: (1) the total effective rate of 30 children with Chinese and Western medicine treated with traditional Chinese medicine and traditional Chinese medicine was 86.67%, superior to that of the conventional western medicine treatment control group (63.33% (P=0.036)). The total recurrence rate of the Chinese and Western medicine treatment group was 9.99%, lower than that of the western medicine control group (16.66% (P=0.029)). (3) the improvement of the onset time of the clinical symptoms (rash, joint pain, and stool) in the treatment group of Chinese and Western Medicine (P=0.029). (6.73- + -3.40,3.24 + 1.64,1.88 + 0.83) days, significantly shorter than the western medicine control group (9.43 + 3.95,3.29 + 1.20,4.71 + -2.69) days, P 0.05. (4) in the western medicine treatment group after treatment, the serum LTB4, VEGF level was lower than the western medicine routine treatment group (P 0.05), the difference was significant.
Conclusion: the treatment of HSP in children with cold blood and invigorating spleen is effective. It can inhibit the serum level of LTB4 and VEGF in children with HSP, and it has some anti-inflammatory and protective effect on endothelial cells, and it can be used to assist in the treatment of HSP.
【学位授予单位】：福建中医药大学
【学位级别】：硕士
【学位授予年份】：2012
【分类号】：R725.5

【参考文献】