新生儿血清中17-羟孕酮水平的影响因素研究

发布时间：2018-07-05 11:58

  本文选题：-羟孕酮 + 新生儿　； 参考：《中国现代医学杂志》2017年22期

【摘要】：目的探讨新生儿血清17-羟孕酮(17-OHP)浓度的影响因素。方法选取2014年1月-2015年12月在西南医科大学附属医院分娩的1 585例新生儿作为研究对象,所有新生儿均排除先天性肾上腺皮质增生症者。采用时间分辨荧光免疫分析法检测17-OHP浓度,比较不同性别、胎龄、出生体重、分娩方法、胎儿数量、采血日龄、血糖水平、血p H值、有无出现感染、窒息、溶血性黄疸等特征的新生儿血清17-OHP浓度,采用多元线性回归来分析各临床特征与血清17-OHP浓度的关系。结果全部新生儿的血清17-OHP浓度为0~136.8 nmol/L,平均(16.68±6.83)nmol/L。胎龄为≤28周、29~32周、33~36周、37~41周、≥42周的新生儿血17-OHP的浓度分别为(24.23±2.18)、(22.34±3.23)、(18.56±4.54)、(16.10±5.72)及(14.18±2.56)nmol/L,极低出生体重儿、低出生体重儿、正常出生体重儿、巨大儿的新生儿血17-OHP的浓度分别为(23.87±2.25)、(21.84±3.36)、(16.17±6.08)及(14.43±3.18)nmol/L,各组比较差异有统计学意义(P0.05)。多元线性回归结果表明,17-OHP浓度与多个因素有关,按作用从大到小依次为胎龄、出生体重、血p H值、血糖、窒息、感染、采血日龄、溶血性黄疸、分娩方法、胎儿数量。结论新生儿血清17-OHP的浓度受到胎龄、出生体重、酸碱平衡、血糖水平等多个因素的影响,故临床上要全面关注这些因素来综合判断血17-OHP的水平。
[Abstract]:Objective to investigate the influencing factors of 17-hydroxyprogesterone (17-OHP) concentration in neonatal serum. Methods from January 2014 to December 2015, 1 585 newborns who were delivered in the affiliated Hospital of Southwest Medical University were selected as study objects. All the newborns were excluded from congenital adrenocortical hyperplasia. The concentration of 17-OHP was detected by time-resolved fluorescence immunoassay (TLIA). The sex, gestational age, birth weight, delivery method, number of fetuses, age of blood collection, blood glucose level, blood pH value, infection and asphyxia were compared. Multivariate linear regression was used to analyze the relationship between the clinical characteristics and serum 17-OHP concentration in neonates with hemolytic jaundice. Results the serum 17-OHP concentration of all newborns was 0 136.8 nmol / L, with an average of (16.68 卤6.83) nmol / L. The serum concentrations of 17-OHP were (24.23 卤2.18), (22.34 卤3.23), (16.56 卤4.54), (16.10 卤5.72) and (14.18 卤2.56) nmol / L in newborns with gestational age 鈮，

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