联合应用双歧杆菌与谷氨酰胺在合并胃肠功能障碍小儿重症肺炎的疗效观察

发布时间：2018-07-08 13:35

本文选题：儿科 + 重症肺炎　；参考：《中华中医药杂志》2017年04期

【摘要】：目的:观察双歧杆菌三联活菌联合谷氨酰胺对合并胃肠功能障碍的重症肺炎患儿的疗效。方法:2013年1月-2015年12月收治本院儿科重症监护病房治疗的80例合并胃肠功能障碍的重症肺炎患儿,随机分为治疗组和对照组,每组各40例患儿。对照组采用常规综合治疗,治疗组在对照组基础上加用双歧杆菌三联活菌联合谷氨酰胺。观察两组患儿治疗前后血浆D-乳酸和二胺氧化酶含量、多脏器功能障碍及其它并发症发生率、PiO_2/FiO_2改善情况,以评价联合应用双歧杆菌三联活菌与谷氨酰胺对重症肺炎患儿的疗效。结果:治疗组38例,对照组36例完成研究。两组患儿血浆D-乳酸及DAO水平随治疗时间延长逐渐降低,相同时间点治疗组患儿D-乳酸水平显著低于对照组(P0.01)。治疗组患儿多器官功能障碍综合征(MODS)发生率为2.63%,显著低于对照组的19.44%(P0.05);治疗组患儿总体并发症发生率为7.89%,显著低于对照组的80.55%(P0.01);治疗组随时间延长PiO_2/FiO_2逐渐增高,不同时间点均高于对照组(P0.01)。结论:联合应用双歧杆菌三联活菌与谷氨酰胺可以显著改善患儿胃肠功能,降低MODS和其它并发症发生率,改善氧合指数,对重症肺炎起到治疗作用。
[Abstract]:Objective: to observe the efficacy of bifidobacterium combined with glutamine in children with severe pneumonia complicated with gastrointestinal dysfunction. Methods: from January 2013 to December 2015, 80 children with severe pneumonia complicated with gastrointestinal dysfunction in pediatric intensive care unit were randomly divided into treatment group (n = 40) and control group (n = 40). The control group was treated with routine comprehensive therapy, and the treatment group was treated with bifidobacterium combined with glutamine on the basis of the control group. The plasma levels of D-lactic acid and diamine oxidase, the incidence of multiple organ dysfunction and other complications were observed before and after treatment, and the improvement of Pio _ 2 / FiO _ 2 was observed in order to evaluate the effect of combined use of Bifidobacterium triple live bacteria and glutamine in the treatment of children with severe pneumonia. Results: 38 cases in treatment group and 36 cases in control group completed the study. The plasma levels of D-lactic acid and Dao decreased gradually with the prolongation of treatment time, and the levels of D-lactic acid in the treatment group were significantly lower than those in the control group at the same time point (P0.01). The incidence of multiple organ dysfunction syndrome (mods) in the treatment group was 2.63, which was significantly lower than that in the control group (19.44%, P0.05), and the overall complication rate in the treatment group was 7.89, significantly lower than that in the control group (80.55%, P0.01). All the time points were higher than the control group (P0.01). Conclusion: combined use of bifidobacterium combined with glutamine can significantly improve gastrointestinal function, reduce the incidence of mods and other complications, improve oxygenation index, and play a therapeutic role in severe pneumonia.
【作者单位】：河北省儿童医院重症医学科;

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