血清总IgE抗体及特应性过敏原与儿童抽动障碍的临床研究

发布时间：2018-07-08 15:09

  本文选题：抽动障碍 + 儿童　； 参考：《中国人民解放军医学院》2012年硕士论文

【摘要】：目的：抽动障碍（Tic Disorders, TD）病因尚不明确，本文通过对抽动障碍患儿血清总IgE抗体和过敏原特应性IgE（sIgE）抗体进行检测，探讨抽动障碍与变态反应的关系。 方法：本课题采用病例对照研究，对72例抽动障碍患儿和50例变态反应性疾病（Allergic Disorders, AD）患儿进行病史采集和血清总IgE、sIgE检测。分别收集TD组和AD组儿童静脉血3毫升，采用欧蒙医学实验诊断股份公司的特应性过敏原中国组合3检测试剂盒（欧蒙印迹法）进行总IgE、吸入性和食物过敏原sIgE抗体的检测，对数据进行统计学分析。 结果：TD组患儿年龄为3～15岁，，平均年龄（8.88±2.75）岁，男孩明显多于女孩。TD患儿84.7%以眼部、鼻咽喉部症状起病。TD组儿童血清总IgE抗体阳性者为61例，阳性率为84.72％，AD组儿童血清总IgE抗体阳性44例，阳性率为88％；TD组儿童血清过敏原sIgE检测阳性50例，阳性率为69.44％,AD组过敏原sIgE检测阳性37例，阳性率为74％，两组间血清总IgE和过敏原sIgE相比较差异均不显著（p＞0.05）。两组儿童血清总IgE抗体水平在不同等级中的分布无显著性差异（p＞0.05）。抽动障碍组常见的过敏原有屋尘、树组合（榆树/梧桐树/柳树/杨树/柏树）、尘螨组合（屋尘螨/粉尘螨）、淡水鱼组合（鲑鱼，鲈鱼，鲤鱼）、牛奶/巧克力混合，与变态反应性疾病组相似。TD组和AD组≥2种过敏原sIgE阳性检出率相比，差别无统计学意义（p＞0.05）。TD组患儿总IgE等级分布与病程长短无关。 结论：1.抽动障碍患儿与变态反应性疾病患儿的血清总IgE和sIgE抗体阳性率在统计学上无显著差异，抽动障碍患儿血清总IgE水平在不同等级中的分布与变态反应性疾病相类似。2.抽动障碍与变态反应性疾病有一定的相关性，机制尚待进一步研究。
[Abstract]:Objective: the etiology of tic disorders (TD) is not clear. The relationship between tic disorders and allergic reaction was studied by detecting the total IgE antibody and the allergic IgE antibody in children with tic disorder. Methods: a case-control study was conducted in 72 children with tic disorders and 50 children with Allergic disorders (AD). Three milliliters of venous blood were collected from children in TD group and AD group respectively. The total IgE, inhaled and food allergen Siga E antibodies were detected by using the Allergic Allergen Chinese combination 3 Test Kit (OMEBlot) of Ormon Medical Experimental diagnosis Co., Ltd. The data were analyzed statistically. Results the age of the children in the group of 10% TD was 3 to 15 years old, the average age was (8.88 卤2.75) years old. 84.7% of the children with TDs were more boys than girls. 61 cases of children in the group of onset of nasopharyngeal and larynx symptoms were positive for total IgE antibody in serum, and 61 cases were positive for IgE antibody in serum in the group of onset of nasopharynx symptoms. The positive rate of serum total IgE antibody was 44 in AD group, 50 in 88T group, and 37 in AD group, and the positive rate was 740.The positive rate was 84.72AD, and the positive rate was 84.72AD, the positive rate was 84.72AD. There was no significant difference in total IgE and Siga between the two groups (p > 0.05). There was no significant difference in the distribution of serum total IgE antibody between the two groups (p > 0.05). Common allergies to house dust, tree combinations (elm / sycamore / willow / poplar / cypress), dust mites (house dust mites / dust mites), freshwater fish (salmon, bass, carp), milk / chocolate mixture, There was no significant difference in the positive rate of Siga between the two groups (p > 0.05). The distribution of total IgE in TD group was not related to the duration of disease. Conclusion 1. The positive rates of serum total IgE and SiIgE antibodies in children with tic disorder and allergic disease were not significantly different. The distribution of serum total IgE in children with tic disorder in different grades was similar to that in allergic diseases. There is a certain correlation between tic disorder and allergic diseases, and the mechanism needs further study.
【学位授予单位】：中国人民解放军医学院
【学位级别】：硕士
【学位授予年份】：2012
【分类号】：R749.94

【引证文献】

相关硕士学位论文 前1条

1 王雪青;静心制动方治疗抽动障碍疗效观察及与神经递质的相关研究[D];北京中医药大学;2013年

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