某医院新生儿重症监护病房患者感染病原菌种类变迁

发布时间：2018-07-13 11:11

【摘要】：目的研究NICU患者感染病原菌种类的变迁及其耐药情况。方法通过回顾性调查方法,对某医院NICU住院患者连续6年医院感染病原菌种类变化情况及其耐药性进行了调查。结果该医院NICU患者连续6年共送检病原学标本10 971份,分离出病原菌1 876株,阳性率17.10%。其中革兰阴性菌占67.86%,革兰阳性菌占26.44%,真菌占5.70%。连续6年中,临床标本分离的革兰阴性菌呈现下降趋势,而革兰阳性菌和真菌分离率则出现上升趋势。革兰阴性菌优势菌为肺炎克雷伯菌和大肠埃希菌,革兰阳性菌优势菌为葡萄球菌和B族链球菌。临床分离的革兰阴性菌对头孢类抗菌药物耐药率较高,保持对碳青霉烯类抗菌药物敏感。结论 NICU患者医院感染病原菌仍以革兰阴性菌为主,但革兰阳性球菌和真菌分离率呈现上升趋势。
[Abstract]:Objective to study the variation and drug resistance of pathogenic bacteria in NICU patients. Methods A retrospective investigation was conducted to investigate the variation and drug resistance of nosocomial infection pathogens in NICU patients for 6 consecutive years. Results A total of 10 971 pathogenic specimens were collected from NICU patients in this hospital for 6 consecutive years. 1 876 strains of pathogens were isolated and the positive rate was 17. 10%. Gram-negative bacteria accounted for 67.86%, Gram-positive bacteria 26.44% and fungi 5.70%. In the past 6 years, the Gram-negative bacteria isolated from clinical specimens showed a decreasing trend, while the rates of Gram-positive bacteria and fungi increased. The dominant bacteria of Gram-negative bacteria were Klebsiella pneumoniae and Escherichia coli, and the dominant bacteria of Gram-positive bacteria were Staphylococcus and Group B Streptococcus. The clinical isolates of Gram-negative bacteria showed high resistance to cephalosporins and remained sensitive to carbapenes. Conclusion Gram-negative bacteria are the main pathogens of nosocomial infection in NICU patients, but the isolation rate of Gram-positive cocci and fungi is increasing.
【作者单位】：温州市儿童医院;
【分类号】：R197.32;R722.13

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