不同型肠道病毒感染手足口病儿童的病毒临床特点比较

发布时间：2018-07-13 17:29

【摘要】：目的探讨不同型肠道病毒感染手足口病儿童的病毒临床特点。方法选取2015年1月-2016年6月在医院儿科住院治疗且确诊为手足口病的患儿162例,根据感染病毒不同将其分为CoxA16组91例和EV71组71例,比较两组患儿入院时病毒载量、临床特点、生命体征指标,手、足部皮疹以及口腔疱疹分布。结果循环阈值EV71组为(27.6±3.9),CoxA16组为(25.7±3.7),EV71组循环阈值显著高于CoxA16组,且差异有统计学意义(P0.05);EV71组患儿的病程、热程均长于CoxA16组,EV71组患儿伴随咳嗽比例显著低于CoxA16组,EV71组患儿伴随嗜睡、惊厥、呕吐、肌肉痉挛比例显著高于CoxA16组,且差异有统计学意义(P0.05);EV71组患儿最高体温、最高收缩压、最高舒张压、最快心率、最快呼吸频率以及外周血白细胞计数均显著高于CoxA16组患儿,且差异有统计学意义(P0.05);EV71组患儿上腭、咽峡部、颊粘膜发生口腔溃疡比例显著低于CoxA16组,且差异有统计学意义(P0.05)。结论肠道病毒感染手足口病儿童的病毒载量与病毒的型别有关,EV71型病毒性手足口病不易被察觉,易发生嗜睡、惊厥、呕吐、肌肉痉挛,且生命体征较差,CoxA16型病毒性手足口病易发生咳嗽,口腔溃疡,在临床治疗是一定要区分对待,对控制患儿的病情具有重要意义。
[Abstract]:Objective to investigate the clinical characteristics of different enterovirus infection in children with hand, foot and mouth disease (HFMD). Methods 162 children who were hospitalized in hospital from January 2015 to June 2016 were divided into CoxA16 group (91 cases) and EV71 group (71 cases). The viral load and clinical characteristics of the two groups were compared. Vital signs, hand, foot rash, and oral herpes. Results the circulation threshold of EV71 group was (27.6 卤3.9) CoxA16 group was significantly higher than that of CoxA16 group (25.7 卤3.7) group, and the difference was statistically significant (P0.05). The course of disease and fever course of EV71 group were significantly longer than those of CoxA16 group EV71 group were significantly lower than that of CoxA16 group EV71 group. The proportion of vomiting and muscle spasm was significantly higher than that of CoxA16 group (P0.05). The highest body temperature, systolic pressure, diastolic blood pressure, fastest heart rate, fastest respiration frequency and white blood cell count in peripheral blood of EV71 group were significantly higher than those in CoxA16 group. The incidence of oral ulcers in EV71 group was significantly lower than that in CoxA16 group (P0.05), and the incidence of oral ulcers in upper palate, pharynx isthmus and buccal mucosa in EV71 group was significantly lower than that in CoxA16 group (P0.05). Conclusion the viral load of enterovirus infection in children with HFMD is related to the type of the virus. It is difficult to detect EV71 virus HFMD, and is prone to lethargy, convulsion, vomiting and muscle spasm. CoxA16 virus hand, foot and mouth disease is prone to cough and oral ulcers. It must be treated differently in clinical treatment, which is of great significance to the control of children's disease.
【作者单位】：滁州市第一人民医院检验中心;滁州市疾病控制中心检验科;湖北中医药大学检验学院;
【分类号】：R725.1

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