中国0～6岁儿童孤独症谱系障碍患病率的meta分析

发布时间：2018-07-15 17:23

【摘要】：目的:了解中国0~6岁儿童孤独症谱系障碍(autism spectrum disorders,ASD)流行现状及趋势。方法:在Pubmed、Web of Science、Scopus、相关期刊论文(CNKI)、万方数据库、维普数据库(VIP)和中国生物医学文献数据库(CBM)检索于2017年2月25日之前发表的关于中国0~6岁儿童孤独症谱系障碍及其亚型患病率研究的文献,按照设定的纳入和诊断标准进行筛选。采用随机效应模型合并不同时期和不同性别儿童患病率数据,并根据数据来源、年龄、筛查和诊断工具、文献质量进行亚组分析。结果:共有9篇ASD患病率文献和20篇孤独症(autism or autistic disorder,AD)患病率文献纳入研究。2006—2010年和2011—2015年0~6岁儿童AD合并患病率分别为1.74‰(95%CI:1.12‰~2.69‰)和1.80‰(95%CI:1.33‰~2.43‰),差异无统计学意义(P=0.898),但均显著高于1996—2005年合并患病率0.94‰(95%CI:0.67‰~1.33‰)(P=0.031;P=0.005)。0~6岁儿童ASD合并患病率在2006—2010年和2011—2015年分别为3.52‰(95%CI:1.48‰~8.34‰)和3.48‰(95%CI:1.77‰~6.84‰),差异未见统计学意义(P=0.983)。不同性别ASD和AD患病率在不同时期差异均无统计学意义。合并得到2006—2015年0~6岁儿童ASD和AD患病率分别为3.51‰(95%CI:2.15‰~5.74‰)和1.77‰(95%CI:1.40‰~2.24‰),男女患病率比分别为2.59∶1和3.63∶1。亚组分析提示月龄和文献质量与ASD或AD合并患病率相关。结论:2006—2015年中国0~6岁儿童ASD和AD患病率均保持稳定,相比2005年以前是否呈上升趋势难以定论。建议开展全国代表性儿童早期ASD和AD现况调查与监测,准确估计ASD及AD流行现状和趋势。
[Abstract]:Objective: to investigate the prevalence and trend of autism spectrum disorders (autism spectrum disorders) in 6 year old children in China. Methods: the Chinese Journal Full-text Database (CNKI) and Wanfang Database were used in Pubmedus Web of Science Scopus. Weip Database (VIP) and Chinese Biomedical Literature Database (CBM) were used to retrieve the literature published before February 25, 2017 on the prevalence of autism spectrum disorders and their subtypes in Chinese 0- and 6-year-old children. Screen according to established inclusion and diagnostic criteria. The random effect model was used to combine the prevalence data of children of different periods and different genders, and subgroup analysis was carried out according to the data source, age, screening and diagnostic tools, and literature quality. Results: a total of 9 articles on the prevalence of ASD and 20 articles on the prevalence of (autism or autistic disorderosis AD were included in the study. The prevalence rate of AD in children aged 6 years from 2006 to 2010 and from 2011 to 2015 was 1.74 鈥，

本文编号：2124818