硫酸特布他林雾化液和布地奈德混悬液联合多索茶碱治疗变异性哮喘患儿的临床研究

发布时间：2018-07-19 19:59

【摘要】：目的观察两种不同雾化吸入方式吸入硫酸特布他林和布地奈德联合多索茶碱治疗变异性哮喘患儿的临床疗效及安全性。方法将78例变异性哮喘患儿随机分为对照组39例与试验组39例。2组均给予常规治疗及对症治疗。对照组采用超声雾化吸入的方式,2组试验组采用空气压缩泵雾化吸入的方式,均给予硫酸特布他林雾化液2 mL+布地奈德混悬液2 mL+0.9%Na Cl 20 mL,每日2次。2组均给予多索茶碱5 mg·kg~(-1)+5%葡萄糖溶液50 mL,静脉滴注,每日1次。2组患儿均治疗5 d。比较2组患儿的临床疗效、外周血嗜酸粒细胞(EOS)、嗜酸性粒细胞阳离子蛋白(ECP)、免疫球蛋白E(IgE)、白细胞介素-4(IL-4)水平及药物不良反应发生情况。结果治疗后,试验组总有效率为92.31%(36例/39例),对照组为74.36%(29例/39例,P0.05)。治疗后,对照组和试验组外周血嗜酸粒细胞分别为(0.79±0.10)×10~9/L,(0.54±0.07)×10~9/L,IgE分别为(176.49±20.11),(107.49±14.44)U·mL~(-1),IL-4分别为(80.92±9.78),(50.98±6.44)ng·mL~(-1),差异均有统计学意义(均P0.05)。对照组和试验组第1秒用力呼气容积分别为(0.64±0.10),(0.70±0.12)L,用力肺活量分别为(2.38±0.29),(3.38±0.37)L,第1秒用力呼气容积占用力肺活量的比值分别为80.39±8.98,90.88±10.02,均显著高于治疗前,且试验组显著高于对照组(P0.05)。2组的药物不良反应均为胃肠道不适和皮疹,试验组和对照组的药物不良反应发生率分别为5.13%(2例/39例),7.69%(3例/39例),差异无统计学意义(P0.05)。结论空气压缩泵雾化吸入方式联合多索茶碱治疗小儿变异性哮喘临床疗效显著高于超声雾化方式,安全性高。
[Abstract]:Objective to observe the efficacy and safety of inhaled terbutaline sulfate and budesonide combined with doxofylline in the treatment of children with variant asthma. Methods 78 children with variant asthma were randomly divided into control group (39 cases) and experimental group (39 cases). The control group was inhaled by ultrasonic atomization. All patients were given 2 mL budesonide suspension of 2 mL budesonide sulfate, 20 mL NaCl, 50 mL doxophylline 5 mg kg ~ (-1) 5% glucose solution twice a day for 5 days. The clinical efficacy, eosinophil (EOS), eosinophil cationic protein (ECP), immunoglobulin E (IgE), interleukin-4 (IL-4) levels and adverse drug reactions were compared between the two groups. Results after treatment, the total effective rate was 92.31% (36 / 39) in the trial group and 74.36% (29 / 39) in the control group (P0.05). After treatment, the eosinophils in peripheral blood of the control group and the experimental group were (0.79 卤0.10) 脳 10 ~ (9) / L, (0.54 卤0.07) 脳 10 ~ (9) L ~ (-1), (176.49 卤20.11), (卤14.44) U mL ~ (-1) IL-4, respectively (80.92 卤9.78), (, 50.98 卤6.44) ng mL ~ (-1), respectively (P 0.05). The forced expiratory volume was (0.64 卤0.10), (卤0.12) L, forced vital capacity was (2.38 卤0.29), (卤3.38 卤0.37) L in the control group and the experimental group, respectively. The ratio of forced expiratory volume occupying capacity in the first second was 80.39 卤8.98 卤90.88 卤10.02, which was significantly higher than that before treatment. The adverse drug reactions in the trial group were significantly higher than those in the control group (P0.05). The incidence of adverse drug reactions in the trial group and the control group was 5.13% (2 / 39 cases) and 7.69% (3 / 39 cases) respectively. The difference was not statistically significant (P0.05). Conclusion the clinical efficacy of aerosol inhalation with air compression pump combined with doxofylline in the treatment of children with variant asthma is significantly higher than that in ultrasonic atomization.
【作者单位】：余姚市第二人民医院儿科;
【基金】：浙江省卫生适宜技术成果转化计划基金资助项目(2011ZHB012)
【分类号】：R725.6

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