重症EV71型手足口病炎症因子的临床意义
发布时间：2018-07-25 18:11
【摘要】：目的了解5种炎症因子MCP-1、IL-1β、IL-18、HMGB1、IL-10在重症EV71型手足口病(HFMD)中的临床意义。方法选取某院2014年3—8月确诊为重症EV71型HFMD的住院患儿为HFMD组,同期本院门诊体检的健康儿童为对照组,动态观察两组外周血MCP-1、IL-1β、IL-18、HMGB1、IL-10表达水平的变化,并收集HFMD组临床资料。结果 HFMD组共102例患儿,平均年龄为(2.18±0.91)岁,其中主要以≤3岁为主,占80.39%;HFMD组患儿入院时为第2期77例,第3期16例,第4期9例。经过第2期共77例,第3期共52例,第4期共21例,第5期共88例。HFMD组第2、3、4期分别与对照组的5种炎症因子表达水平比较,差异均有统计学意义(均P0.05);HFMD组第3期与第4期的IL-10表达水平比较,差异无统计学意义(P0.05)。HFMD组第2、3期进展组HMGB1表达水平均高于痊愈组,差异均有统计学意义(均P0.05)。死亡组与存活组在入院时5种炎症因子表达水平的比较,差异均有统计学意义(均P0.05)。结论 MCP-1、HMGB1、IL-1β、IL-10、IL-18的表达水平与HFMD病情轻重相关,对患儿预后的预测有一定临床意义。HMBG1在HFMD中对病情转归有一定预测价值。
[Abstract]:Objective to investigate the clinical significance of five inflammatory cytokines MCP-1IL-1 尾 IL-18 HMGB1mIL-10 in (HFMD) of severe EV71's hand, foot and mouth disease (HFMD). Methods the hospitalized children with severe EV71 type HFMD from March to August 2014 were selected as the HFMD group and the healthy children in our outpatient examination as the control group. The expression of IL-10 in the peripheral blood of the two groups was observed dynamically, and the clinical data of the HFMD group were collected. Results there were 102 children in HFMD group, the average age was (2.18 卤0.91) years old. Most of them were 鈮，
本文编号：2144622
[Abstract]:Objective to investigate the clinical significance of five inflammatory cytokines MCP-1IL-1 尾 IL-18 HMGB1mIL-10 in (HFMD) of severe EV71's hand, foot and mouth disease (HFMD). Methods the hospitalized children with severe EV71 type HFMD from March to August 2014 were selected as the HFMD group and the healthy children in our outpatient examination as the control group. The expression of IL-10 in the peripheral blood of the two groups was observed dynamically, and the clinical data of the HFMD group were collected. Results there were 102 children in HFMD group, the average age was (2.18 卤0.91) years old. Most of them were 鈮，
本文编号：2144622
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