女性青少年系统性红斑狼疮患者外貌改变与抑郁症状的关系探讨
发布时间：2018-07-28 09:52
【摘要】：目的探讨外貌评分与女性青少年系统性红斑狼疮(systemic lupus erythematosus, SLE)患者抑郁症状之间的关系。 方法选取42名青少年女性SLE患者作为患者组,40名年龄段相同的女性受试者作为对照组,对患者组及对照组受试者实施问卷调查。调查内容包括系统性红斑狼疮疾病活动性指数(systemic lupus erythematosis disease activity index, SLEDAI)量表评价SLE疾病严重程度,儿童抑郁量表(children's depression inventory, CDI)评价儿童抑郁情况,儿童自我感知量表(self-perception profile for children, SPPC)中的外貌评价项目进行外貌评分。所有的分析均采用SPSS10.0进行数据分析。t检验比较正态分布数据差异,Spearman相关分析进行相关性研究,多分类有序Logistic回归分析,p0.05定义为显著性差异,检验水准α=0.05。 结果患者组中几乎所有的患者均表现出不同程度的抑郁症状。患者组CDI总分平均为18.5±4.3,38.1%(16／42)的患者CDI大于19分。对照组CDI分数显著低于患者组(11.4±1.7vs.18.54±4.3,p0.05)。92.9%(39／42)的SLE患者表示因为SLE而变得对自身相貌不满意。这些患者中,SPPC外貌得分为13.0±2.8,而对照组儿童外貌评价得分为20.0±3.1(p0.05)。单因素Pearson相关分析评价年龄、病程、SLEDAI评分、住院次数、外貌评分及CDI评分之间的关系。外貌评分与抑郁症状高度相关(r=-0.758,p=0.001),其他因素如病程、SLEDAI评分及住院次数仪与抑郁症状部分相关。狼疮脑病组患儿与非狼疮脑病组患儿抑郁症状发病率无显著区别。 结论外貌改变与青少年女性SLE患者出现抑郁症状有较为显著的相关性,提示我们在治疗时应充分重视缓解与外貌相关的症征,尽可能减少各种治疗对外貌带来的影响,并应加强此方面的心理辅导。此外,狼疮脑病与患儿抑郁症状无显著关联。
[Abstract]:Objective to investigate the relationship between appearance score and depressive symptoms in female adolescent patients with systemic lupus erythematosus (systemic lupus erythematosus, SLE). Methods 42 adolescent female SLE patients were selected as the control group and 40 female subjects of the same age group as the control group. The subjects in the patient group and the control group were investigated by questionnaire. The contents of the investigation included the evaluation of the severity of SLE disease with the activity index of systemic lupus erythematosus (systemic lupus erythematosis disease activity index, SLEDAI) and the evaluation of depression in children with (children's depression inventory, CDI). Children's self-perception scale (self-perception profile for children, SPPC) was used to evaluate appearance. All the analyses were carried out by SPSS10.0 data analysis. T test was used to compare the normal distribution data difference and Spearman correlation analysis. The multi-classification ordered Logistic regression analysis was defined as significant difference, and the test level was 伪 0.05. Results almost all patients in the patient group showed different degree of depression. The average total score of CDI in patients was 18.5 卤4.3 卤38.1% (16 / 42), CDI was greater than 19. CDI scores in the control group were significantly lower than those in the patient group (11.4 卤1.7vs.18.54 卤4.3 p0.05). 92.9% (39 / 42) of SLE patients indicated that they were not satisfied with their appearance because of SLE. In these patients, the SPPC appearance score was 13.0 卤2.8, while that in the control group was 20.0 卤3.1 (p0.05). Univariate Pearson correlation analysis was used to evaluate the relationship between age, course of disease and SLEDAI score, hospitalization frequency, appearance score and CDI score. There was a high correlation between appearance score and depression symptoms (r = -0.758p0. 001). Other factors, such as the SLEDAI score of course of disease and the frequency of hospitalization, were partly related to depression symptoms. There was no significant difference in the incidence of depressive symptoms between children with lupus encephalopathy and those with non-lupus encephalopathy. Conclusion there is a significant correlation between appearance changes and depressive symptoms in adolescent female SLE patients, which suggests that we should pay more attention to alleviating the symptoms associated with appearance and minimize the effects of various treatments on appearance. Psychological counseling in this area should be strengthened. In addition, there was no significant association between lupus encephalopathy and depressive symptoms in children.
【学位授予单位】：北京协和医学院
【学位级别】：硕士
【学位授予年份】：2012
【分类号】：R725.9
本文编号：2149713
[Abstract]:Objective to investigate the relationship between appearance score and depressive symptoms in female adolescent patients with systemic lupus erythematosus (systemic lupus erythematosus, SLE). Methods 42 adolescent female SLE patients were selected as the control group and 40 female subjects of the same age group as the control group. The subjects in the patient group and the control group were investigated by questionnaire. The contents of the investigation included the evaluation of the severity of SLE disease with the activity index of systemic lupus erythematosus (systemic lupus erythematosis disease activity index, SLEDAI) and the evaluation of depression in children with (children's depression inventory, CDI). Children's self-perception scale (self-perception profile for children, SPPC) was used to evaluate appearance. All the analyses were carried out by SPSS10.0 data analysis. T test was used to compare the normal distribution data difference and Spearman correlation analysis. The multi-classification ordered Logistic regression analysis was defined as significant difference, and the test level was 伪 0.05. Results almost all patients in the patient group showed different degree of depression. The average total score of CDI in patients was 18.5 卤4.3 卤38.1% (16 / 42), CDI was greater than 19. CDI scores in the control group were significantly lower than those in the patient group (11.4 卤1.7vs.18.54 卤4.3 p0.05). 92.9% (39 / 42) of SLE patients indicated that they were not satisfied with their appearance because of SLE. In these patients, the SPPC appearance score was 13.0 卤2.8, while that in the control group was 20.0 卤3.1 (p0.05). Univariate Pearson correlation analysis was used to evaluate the relationship between age, course of disease and SLEDAI score, hospitalization frequency, appearance score and CDI score. There was a high correlation between appearance score and depression symptoms (r = -0.758p0. 001). Other factors, such as the SLEDAI score of course of disease and the frequency of hospitalization, were partly related to depression symptoms. There was no significant difference in the incidence of depressive symptoms between children with lupus encephalopathy and those with non-lupus encephalopathy. Conclusion there is a significant correlation between appearance changes and depressive symptoms in adolescent female SLE patients, which suggests that we should pay more attention to alleviating the symptoms associated with appearance and minimize the effects of various treatments on appearance. Psychological counseling in this area should be strengthened. In addition, there was no significant association between lupus encephalopathy and depressive symptoms in children.
【学位授予单位】：北京协和医学院
【学位级别】：硕士
【学位授予年份】：2012
【分类号】：R725.9
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