川芎嗪注射液治疗小儿重症肺炎疗效及对痰液炎症因子影响

发布时间：2018-07-31 14:42

【摘要】：目的:分析川芎嗪注射液对小儿重症肺炎的疗效及对痰液炎症因子影响。方法:我院儿内科2015年9月~2017年2月期间收治的114例重症肺炎患儿作为对象进行分析,根据入院顺序抽取偶数组为对照组,该组给予常规对症方案治疗,奇数组为观察组,该组在常规治疗基础上加用川芎嗪注射液,分析川芎嗪注射液对患儿疗效的影响。结果:(1)在总有效率上,观察组为96.49%,明显高于对照组80.70%。观察组死亡率5.26%和对照组8.77%比,差异无统计学意义。观察组体温恢复正常、咳嗽消失、呼吸困难消失和肺Up音消失时间分别为(3.19±0.69、6.49±1.27、4.29±1.01、5.86±1.24)d,均明显短于对照组(4.58±1.02、8.30±1.59、6.13±1.15、8.06±1.53)d。(3)治疗后,观察组MMF、PEF、RR分别为(1.69±0.17L/s、2.08±0.21L/s、30.19±3.81次/min),均明显优于对照组(1.24±0.14L/s、1.61±0.16L/s、35.90±4.28次/min)。(4)治疗后,观察组痰液中TNF-ɑ、IL-10水平分别为(22.08±3.51、26.19±5.20)pg/ml,均明显低于对照组(27.69±3.73、32.08±5.42)pg/ml。(5)观察组发生7.02%的不良反应,和对照组8.77%比,差异无统计学意义。结论:川芎嗪注射液可用于小儿重症肺炎的联合用药,其可加快控制患儿炎症,改善肺功能,提高治疗效果。
[Abstract]:Objective: to analyze the effect of Ligustrazine Injection on severe pneumonia in children and to influence the inflammatory factors of sputum. Methods: 114 cases of severe pneumonia in the Department of medicine of our hospital in September 2015 ~2017 February were analyzed and the even numbered groups were selected according to the order of admission. The group was treated with routine symptomatic treatment, and the odd group was the view. On the basis of routine treatment, the group used ligustrazine injection to analyze the effect of Ligustrazine Injection on the curative effect of the children. Results: (1) in the total effective rate, the observation group was 96.49%, obviously higher than the control group 80.70%. observation group mortality 5.26% and the control group 8.77% ratio, the difference was not statistically significant. The body temperature recovered to normal, cough disappeared, The disappearance of dyspnea and the disappearance time of lung Up sound were (3.19 + 0.69,6.49 + 1.27,4.29 + 1.01,5.86 + 1.24) d respectively, which were significantly shorter than those of the control group (4.58 + 1.02,8.30 + 1.59,6.13 + 1.15,8.06 + 1.53) d. (3), and the observation group was MMF, PEF, respectively (1.69 + 2.08, 2.08 +, 30.19 + 3.81 times), which were significantly better than those of the control group (1.24 + 3, 1.. 61 + 0.16L/s, 35.90 + 4.28 times /min). (4) after treatment, the level of TNF- in the sputum in the observation group was (22.08 + 3.51,26.19 + 5.20) pg/ml respectively, which was significantly lower than that of the control group (27.69 + 3.73,32.08 + 5.42) pg/ml. (5) pg/ml. (5) group and 7.02% adverse reactions, and the difference was not statistically significant between the control group and the control group. Conclusion: ligustrazine injection can be used for small difference. Combined use of pediatric severe pneumonia can accelerate the control of inflammation, improve lung function and improve the therapeutic effect.
【作者单位】：胜利油田中心医院;中国石化集团胜利石油管理局胜利医院;
【分类号】：R272

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