细菌溶解产物胶囊治疗哮喘急性发作患儿的临床观察

发布时间：2018-08-02 15:30

【摘要】：目的:探讨细菌溶解产物胶囊治疗哮喘急性发作患儿的临床疗效及对炎症因子、肺功能指标、呼吸力学指标的影响。方法:选取2013年9月-2016年1月我院收治的哮喘急性发作患儿87例,按随机数字表法分为观察组(44例)和对照组(43例)。对照组患儿给予糖皮质激素丙酸倍氯米松气雾剂0.05 mg,tid;观察组患儿在对照组基础上加用细菌溶解产物胶囊3.5 mg,qd。两组患儿疗程均为120 d。观察两组患儿外周血Th1/Th2细胞因子水平[γ干扰素(IFN-γ)、白细胞介素2(IL-2)、IL-4、IL-5、IL-10、IL-13]、肺功能指标[用力肺活量(FVC)、第一秒用力呼气容积(FEV1)、呼气峰流速(PEF)]、呼吸力学指标(平均气道压、呼吸阻力、静态顺应性、平台压测定值)及临床疗效。结果:治疗前,两组患儿Th1/Th2细胞因子、肺功能指标、呼吸力学指标比较,差异均无统计学意义(P0.05);治疗后,两组患儿IFN-γ、IL-2、IL-10、FVC、FEV1、PEF水平均显著升高,IL-5、IL-13水平均显著降低,对照组患儿IL-4水平显著降低,且观察组患儿IL-2、IL-4、IL-10、FVC、FEV1、PEF水平显著优于对照组,差异均有统计学意义(P0.05)。观察组患儿的平均气道压、呼吸阻力、平台压测定值均显著低于对照组,静态顺应性显著高于对照组,差异均有统计学意义(P0.05)。观察组患儿控显率为77.27%,显著高于对照组的55.81%,差异有统计学意义(P0.05)。结论:细菌溶解产物胶囊治疗哮喘急性发作患儿疗效显著,能够明显减轻患儿气道炎症反应、提高机体免疫水平,从而改善气道呼吸力学参数。
[Abstract]:Objective: to investigate the clinical effect of bacterial lytic product capsule in treating children with acute asthma attack and its influence on inflammatory factors, pulmonary function index and respiratory mechanics index. Methods: 87 children with acute attack of asthma from September 2013 to January 2016 were randomly divided into observation group (n = 44) and control group (n = 43). The children in the control group were given corticosteroid propionate beclomethasone aerosol (0.05 mg / kg), and the control group was given 3.5 mg / kg bacterial dissolving product capsule on the basis of the control group. The course of treatment was 120 days in both groups. The levels of Th1/Th2 cytokines in peripheral blood [interferon 纬 (IFN- 纬), interleukin-2 (IL-2) IL-4IL-5IL-10 IL-13], pulmonary function [forced expiratory volume (FEV1) in the first second of forced vital capacity (FVC), peak expiratory flow (PEF)] and respiratory mechanics (mean airway pressure, respiratory resistance) were observed in both groups. Static compliance, plateau pressure measurement) and clinical efficacy. Results: before treatment, there was no significant difference in Th1/Th2 cytokines, pulmonary function and respiratory mechanics between the two groups (P0.05), and after treatment, the levels of IL-2IL-10, FVCFEV1 / PEF in the two groups were significantly increased and IL-5 / IL-13 levels were significantly decreased. The level of IL-4 in the control group was significantly lower than that in the control group, and the level of IL-2, IL-4, IL-10 and FEV1PEF in the observation group was significantly higher than that in the control group (P0.05). The mean airway pressure, respiratory resistance and plateau pressure in the observation group were significantly lower than those in the control group, and the static compliance was significantly higher than that in the control group (P0.05). The control rate of the observation group was 77.27, significantly higher than that of the control group 55.81, the difference was statistically significant (P0.05). Conclusion: the bacteriolysis product capsule is effective in the treatment of children with acute asthma attack, which can obviously reduce the airway inflammation, improve the immune level and improve the respiratory mechanical parameters of the airway.
【作者单位】：齐齐哈尔医学院第一附属医院儿科;齐齐哈尔医学院第一附属医院肿瘤内科;
【分类号】：R725.6

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