维生素D与儿童支气管哮喘的相关性研究
发布时间：2018-08-03 06:48
【摘要】：目的本实验通过对维生素D治疗前后支气管哮喘患儿血清25-(OH)D水平的检测,观察25-(OH)D水平在哮喘患儿体内的变化;探讨维生素D与儿童支气管哮喘之间的关系,为小儿支气管哮喘的防治寻求新的治疗靶点和临床方法。方法选取2015年9月--2016年9月在延安大学附属医院儿科就诊的支气管哮喘患儿98例,将98例哮喘患儿随机分为两组:即实验组(维生素D治疗组)和观察组(非维生素D治疗组);两组患儿(有急性发作的待急性症状控制后)均给与控制症状等哮喘规范化治疗,实验组(维生素D治疗组)患儿除常规治疗外,给予补充维生素D(800iu/日)治疗3个月;同时随机抽取来我院体检的健康儿童50例作为对照组,治疗前后分别测定实验组(维生素D治疗组)和观察组(非维生素D治疗组)两组患儿血清25-(OH)D水平;对照组(健康儿童)在入院体检时用同样方法检测血清25-(OH)D水平,观察记录实验组(维生素D治疗组)和观察组(非维生素D治疗组)两组患儿的哮喘控制情况。结果1.支气管哮喘患儿血清25-(OH)D水平比正常健康儿童降低,两组间差异具有统计学意义(P0.05)。2.治疗前实验组(维生素D治疗组)和观察组(非维生素D治疗组)两组患儿血清25-(OH)D水平差别不明显,差异无统计学意义(P0.05);治疗后实验组(维生素D治疗组)和观察组(非维生素D治疗组)患儿血清25-(OH)D水平都较治疗前升高,实验组(维生素D治疗组)较观察组(非维生素D治疗组)组升高明显,两组差异具有统计学意义(P0.05)。3.实验组(维生素D治疗组)和观察组(非维生素D治疗组)治疗后血清25-(OH)D水平较治疗前升高,实验组(维生素D治疗组)升高幅度大,但和对照组(健康儿童)相比仍有差异,具有统计学意义(P0.05)4.实验组(维生素D治疗组)在治疗中给予补充一定剂量的维生素D后,实验组(维生素D治疗组)较观察组(非维生素D治疗组)控制率升高,两组之间比较差异有统计学意义(P0.05)。结论1.维生素D在儿童支气管哮喘的发生、发展中起着一定的作用;维生素D缺乏或不足可能是哮喘的发病因素之一。2.支气管哮喘患儿血清维生素D水平明显低于健康儿童,对哮喘患儿进行补充维生素D治疗后,患儿的哮喘控制情况明显好转。3.维生素D可能对小儿支气管哮喘的预防、控制起着积极的作用。
[Abstract]:Objective To observe the serum level of 25- (OH) D in children with bronchial asthma before and after vitamin D treatment, observe the changes of 25- (OH) D level in children with asthma, explore the relationship between vitamin D and bronchial asthma in children, and seek new therapeutic targets and clinical methods for the prevention and treatment of bronchial asthma in children. Methods selected in 2015 9 In September, --2016, 98 children with bronchial asthma in Affiliated Hospital of Yan'an University, 98 children with asthma were randomly divided into two groups: the experimental group (vitamin D treatment group) and the observation group (non vitamin D treatment group), and the two groups of children (after acute attack to acute disease control) were all given standardized treatment of asthma control, such as control symptoms. The group (vitamin D treatment group) was treated with vitamin D (800iu/ day) for 3 months, and 50 healthy children in our hospital were randomly selected as the control group. The serum 25- (OH) D levels of the experimental group (vitamin D treatment group) and the observation group (non vitamin D treatment group) were measured before and after treatment, and the control group was compared with the control group. Group (healthy children) detected the serum 25- (OH) D level by the same method at admission, observed the control of asthma in the two groups of the experimental group (vitamin D treatment group) and the observation group (non vitamin D treatment group). Results the serum 25- (OH) D level of the children with 1. bronchial asthma was lower than that of the normal healthy children. The difference between the two groups was statistically significant. There was no significant difference in serum 25- (OH) D level between the two groups of the experimental group (vitamin D treatment group) and the observation group (non vitamin D treatment group). The serum 25- (OH) levels in the experimental group (vitamin D treatment group) and the observation group (non vitamin D treatment group) were all higher than before the treatment, and the experimental group was higher than before treatment, and the experimental group was higher than before treatment, and the experimental group was higher than before treatment, the experiment was higher than before treatment, the experiment was higher than before treatment. Group (vitamin D treatment group) was significantly higher than that in the observation group (non vitamin D treatment group), the difference between the two groups was statistically significant (P0.05).3. experimental group (vitamin D treatment group) and the observation group (non vitamin D treatment group) after treatment, the serum 25- (OH) D level was higher than before the treatment, the experimental group (vitamin D treatment group) increased significantly, but the control group (healthy) Kang Ertong) compared with the difference, with statistical significance (P0.05) 4. experimental group (vitamin D treatment group) supplemented with a certain dose of vitamin D in the treatment group (vitamin D treatment group) compared with the observation group (non vitamin D treatment group) control rate increased, the difference between the two groups was statistically significant (P0.05). Conclusion 1. vitamin D in children The development of child bronchial asthma plays a role in the development of a certain role. Vitamin D deficiency or deficiency may be one of the factors of asthma. Serum vitamin D levels in children with bronchial asthma are obviously lower than those of healthy children. After supplementing vitamin D for children with asthma, the control of asthma in children is obviously better than that of.3. vitamin D, and the possibility of vitamin D is possible. Prevention and control of bronchial asthma play a positive role in children.
【学位授予单位】：延安大学
【学位级别】：硕士
【学位授予年份】：2017
【分类号】：R725.6
本文编号：2160881
[Abstract]:Objective To observe the serum level of 25- (OH) D in children with bronchial asthma before and after vitamin D treatment, observe the changes of 25- (OH) D level in children with asthma, explore the relationship between vitamin D and bronchial asthma in children, and seek new therapeutic targets and clinical methods for the prevention and treatment of bronchial asthma in children. Methods selected in 2015 9 In September, --2016, 98 children with bronchial asthma in Affiliated Hospital of Yan'an University, 98 children with asthma were randomly divided into two groups: the experimental group (vitamin D treatment group) and the observation group (non vitamin D treatment group), and the two groups of children (after acute attack to acute disease control) were all given standardized treatment of asthma control, such as control symptoms. The group (vitamin D treatment group) was treated with vitamin D (800iu/ day) for 3 months, and 50 healthy children in our hospital were randomly selected as the control group. The serum 25- (OH) D levels of the experimental group (vitamin D treatment group) and the observation group (non vitamin D treatment group) were measured before and after treatment, and the control group was compared with the control group. Group (healthy children) detected the serum 25- (OH) D level by the same method at admission, observed the control of asthma in the two groups of the experimental group (vitamin D treatment group) and the observation group (non vitamin D treatment group). Results the serum 25- (OH) D level of the children with 1. bronchial asthma was lower than that of the normal healthy children. The difference between the two groups was statistically significant. There was no significant difference in serum 25- (OH) D level between the two groups of the experimental group (vitamin D treatment group) and the observation group (non vitamin D treatment group). The serum 25- (OH) levels in the experimental group (vitamin D treatment group) and the observation group (non vitamin D treatment group) were all higher than before the treatment, and the experimental group was higher than before treatment, and the experimental group was higher than before treatment, and the experimental group was higher than before treatment, the experiment was higher than before treatment, the experiment was higher than before treatment. Group (vitamin D treatment group) was significantly higher than that in the observation group (non vitamin D treatment group), the difference between the two groups was statistically significant (P0.05).3. experimental group (vitamin D treatment group) and the observation group (non vitamin D treatment group) after treatment, the serum 25- (OH) D level was higher than before the treatment, the experimental group (vitamin D treatment group) increased significantly, but the control group (healthy) Kang Ertong) compared with the difference, with statistical significance (P0.05) 4. experimental group (vitamin D treatment group) supplemented with a certain dose of vitamin D in the treatment group (vitamin D treatment group) compared with the observation group (non vitamin D treatment group) control rate increased, the difference between the two groups was statistically significant (P0.05). Conclusion 1. vitamin D in children The development of child bronchial asthma plays a role in the development of a certain role. Vitamin D deficiency or deficiency may be one of the factors of asthma. Serum vitamin D levels in children with bronchial asthma are obviously lower than those of healthy children. After supplementing vitamin D for children with asthma, the control of asthma in children is obviously better than that of.3. vitamin D, and the possibility of vitamin D is possible. Prevention and control of bronchial asthma play a positive role in children.
【学位授予单位】：延安大学
【学位级别】：硕士
【学位授予年份】：2017
【分类号】：R725.6
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