微量元素和血铅的变化对抽动症患儿的影响分析

发布时间：2018-08-12 17:48

【摘要】：目的:探究抽动症患儿血清中铅、铜、锌、铁和镁的水平变化,血清中铅、铜、锌、铁和镁与抽动症之间的相关性。方法:选择2012年1月至2016年12月在我院门诊接收治疗的抽动症患儿200例,选择同期在我院进行健康体检的儿童100例。按照儿童是否患有抽动症,将研究对象分为抽动症组和对照组;按照患儿的性别,将抽动症患儿分为男性抽动症组和女性抽动症组;按照患儿的年龄,将抽动症患儿分为幼龄组、学龄前组、学龄组;按照患儿抽动症严重程度,将抽动症患儿分为轻微抽动症组、轻度抽动症组、中度抽动症组、明显抽动症组和严重抽动症组。用原子吸收光谱仪对各组研究对象血清中的铅、铜、锌、铁、和镁水平进行检测。对比各组研究对象血清中铅、铜、锌、铁、和镁水平,用Logistic回归分析,分析血清中铅、铜、锌、铁、和镁与抽动症之间的相关性。结果:(1)抽动症组和对照组的一般临床资料没有显著性差异(P0.05);(2)抽动症组患儿血清中的铅、锌和铁水平与对照组有显著性差异(P0.05),抽动症组患儿血清中铜、镁水平与对照组没有显著性差异(P0.05);(3)抽动症组患儿铅、锌和铁检测值偏于正常值发生率显著性的高于对照组(P0.05);(4)幼龄组、学龄前组和学龄组患儿血清中的铅、铜、锌、铁和镁水平与对照组没有显著性差异(P0.05);(5)男性抽动症组和女性抽动症组患儿血清中的铅、铜、锌、铁和镁水平与对照组没有显著性差异(P0.05);(6)轻微冲动症组、轻度抽动症组、中度抽动症组、明显抽动症组和严重抽动症组患儿血清中的铅、锌和铁水平有显著性差异(P0.05),轻微冲动症组、轻度抽动症组、中度抽动症组、明显抽动症组和严重抽动症组患儿血清中的铜和镁水平没有显著性差异(P0.05);(7)低水平的锌和铁是儿童发生抽动症的危险因素,高水平的铅是儿童发生抽动症的危险因素。结论:(1)抽动症患儿血清中的血铅水平高于正常儿童,过高的血铅水平是儿童发生抽动症的危险因素;(2)抽动症患儿血清中的锌和铁水平低于正常儿童,过低的血锌和血铁水平是儿童发生抽动症的危险因素;(3)抽动症患儿血清中的铜、镁水平与正常儿童没有显著性的差。
[Abstract]:Objective: to investigate the relationship between serum lead, copper, zinc, iron and magnesium levels and serum lead, copper, zinc, iron and magnesium levels in children with tic disorder. Methods: from January 2012 to December 2016, 200 children with tic disorder were selected and 100 children who underwent physical examination in our hospital from January 2012 to December 2016 were selected. According to whether the child has tic disorder or not, the subjects of the study are divided into two groups: the children with tic disorder and the control group; the children with tic disorder are divided into the male group and the female group according to the sex of the child; according to the age of the child, Children with tic were divided into young group, preschool group and school age group. According to the severity of the children's tic disorder, children with tic disorder were divided into mild tic group, moderate tic group, obvious tic group and severe tic group. The levels of lead, copper, zinc, iron and magnesium in serum of each group were determined by atomic absorption spectrometer. The levels of lead, copper, zinc, iron, and magnesium in serum of each group were compared. The correlation of lead, copper, zinc, iron and magnesium with tic was analyzed by Logistic regression analysis. Results: (1) there was no significant difference in general clinical data between the tic group and the control group (P0.05); (2). The levels of lead, zinc and iron in the serum of the children with tic disorder were significantly different from those in the control group (P0.05). There was no significant difference in magnesium level between the control group and the control group (P0.05); (3). The incidence of lead, zinc and zinc in the children with tic disorder was significantly higher than that in the control group (P0.05); (4), the lead, copper, zinc in the serum of preschool group and school age group. There was no significant difference in serum lead, copper, zinc, iron and magnesium levels between male and female patients with tic disorder and control group (P0.05); (5). There was no significant difference in serum levels of lead, copper, zinc, iron and magnesium between male and female patients (P0.05); (6). There were significant differences in serum lead, zinc and iron levels in moderate tic group, obvious tic group and severe tic group (P0.05), mild impulsive disorder group, mild tic disorder group, moderate tic syndrome group, and moderate tic group. There was no significant difference in serum copper and magnesium levels between children with severe tic disorder and those with obvious tic disorder (P0.05); (7). Low levels of zinc and iron were risk factors for children with tic disorder, and high levels of lead were risk factors for children with THD. Conclusion: (1) the serum lead level in children with tic disorder is higher than that in normal children, and the high level of blood lead is the risk factor of children with tic disorder, (2) the serum zinc and iron levels in children with tic disorder are lower than those in normal children. Low serum zinc and iron levels were the risk factors for children with tic. (3) there was no significant difference in serum copper and magnesium levels between children with tic disorder and normal children.
【学位授予单位】：山东大学
【学位级别】：硕士
【学位授予年份】：2017
【分类号】：R749.94

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