运脾止泻颗粒治疗小儿泄泻继发乳糖不耐受的临床研究

发布时间：2018-08-16 13:50

【摘要】：研究目的：通过观察治疗前后小儿泄泻继发乳糖不耐受主要疗效指标的变化,客观评价运脾止泻颗粒治疗小儿泄泻继发乳糖不耐受的临床疗效。研究方法：将符合小儿泄泻继发乳糖不耐受的60例患儿随机分为两组,治疗组和对照组各30例,治疗组予中药颗粒剂敷脐,以苍术、苏梗、葛根、焦山楂为主方,根据临床辨证脾虚证加入木香、草果,湿热证加入黄芩、地锦草,伤食证加入神曲、鸡内金,风寒证加入羌活、佩兰、皂角刺。对照组予礞脱石散联合思连康治疗。两组均以5天为1个疗程,治疗并观察1个疗程。观察两组在治疗前后大便次数、大便质地、大便量、腹胀、呕吐以及食欲等症状积分的改善情况。研究结果：共收集60例符合要求的观察病例,治疗组和对照组各30例。治疗前两组在性别、年龄、病程、症状积分、病情分度等方面的比较,其差异无统计学意义(P0.05),具有可比性。治疗组30例,痊愈7例(23.30%),显效11例(36.7%),有效10例(33.30%),无效2例(6.70%)；对照组30例,痊愈3例(10.00%),显效3例(10.00%),有效15例(50.00%),无效9例(30.00%)。治疗组总有效率93.30%,痊愈显效率60.00%；对照组总有效率70.00%,痊愈显效率20.00%,治疗组在总有效率、痊愈显效率上显著优于对照组,有统计学意义(P0.01)。治疗后两组在总积分、主症积分及次症积分方面比较,差异有显著的统计学意义(P0.01),治疗组优于对照组；其中两组在大便次数、大便量、腹胀、呕吐等方面比较,差异具有统计学意义(P0.05),治疗组优于对照组；然而在大便质地、食欲方面的比较治疗组与对照组没有明显差异(P0.05)。两组治疗期间均未出现不良反应。结论：运脾止泻颗粒治疗小儿泄泻继发乳糖不耐受的疗效优于对照组,而且无明显副作用,是有效、安全的方法,值得临床推广应用。
[Abstract]:Objective: to evaluate the clinical efficacy of Yunpi Zhixie granule in treating diarrhea secondary lactose intolerance in children by observing the changes of main therapeutic indexes before and after treatment. Methods: sixty children with lactose intolerance secondary to diarrhea were randomly divided into two groups: treatment group (n = 30) and control group (n = 30). According to clinical differentiation of spleen deficiency syndrome add wood incense, grass fruit, damp-heat syndrome to add Scutellaria baicalensis, Scutellaria chinensis, food injury syndrome to add Shenqu, chicken gold, wind and cold syndrome to add Notopterygium, Perrin, saponin thorn. The control group was treated with Mengtou Shi San and Silenkang. Both groups were treated with 5 days as a course of treatment and observed a course of treatment. The improvement of defecation times, stool texture, stool quantity, abdominal distension, vomiting and appetite were observed before and after treatment. Results: a total of 60 cases were collected, 30 cases in the treatment group and 30 cases in the control group. There was no significant difference between the two groups in sex, age, course of disease, symptom score, disease grade and so on before treatment (P0.05). In the treatment group, 7 cases (23.30%) were cured, 11 cases (36.7%) were effective, 10 cases (33.30%) were effective, and 2 cases (6.70%) were ineffective, while in the control group, 3 cases (10.00%) were cured, 3 cases (10.00%) were effective, 15 cases (50.00%) were effective, 9 cases (30.00%) were ineffective. The total effective rate of the treatment group was 93.30%, the markedly effective rate of the cure group was 60.000.The total effective rate of the control group was 70.00and the effective rate of the cure group was 20.000.The total effective rate of the treatment group was significantly better than that of the control group (P0.01). After treatment, there were significant differences in total score, main symptom score and secondary symptom score between the two groups (P0.01), the treatment group was better than the control group, and the two groups were compared in defecation times, stool volume, abdominal distension, vomiting and so on. The difference was statistically significant (P0.05), the treatment group was better than the control group; however, there was no significant difference between the treatment group and the control group in stool texture and appetite (P0.05). There were no adverse reactions during treatment in both groups. Conclusion: the efficacy of Yunpi Zhixie granule in treating lactose intolerance secondary to diarrhea in children is better than that in control group, and it is an effective and safe method with no obvious side effects. It is worth popularizing in clinic.
【学位授予单位】：南京中医药大学
【学位级别】：硕士
【学位授予年份】：2013
【分类号】：R272

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