六味地黄丸在病毒性脑炎患儿治疗中的应用效果观察

发布时间：2018-08-17 09:53

【摘要】：目的观察六味地黄丸在病毒性脑炎患儿治疗中的应用效果。方法将68例病毒性脑炎患儿随机分为对照组和观察组各34例,均给予面罩吸氧、静脉补液保持水电解质平衡、营养支持、并发症对症处理、免疫治疗等基础治疗,同时静脉输注阿昔洛韦,观察组加用六味地黄丸治疗,连续治疗3周。治疗前后取脑脊液检测大淋巴细胞、激活淋巴细胞、浆细胞比例,取静脉血检测血清IL-1、TNF-α,记录临床症状改善时间,评价临床疗效,观察药物不良反应。结果两组治疗前脑脊液大淋巴细胞、激活淋巴细胞、浆细胞计数及血清IL-1、TNF-α水平比较差异无统计学意义(P均㧐0.05),治疗3周后两组各指标均较治疗前降低(P均0.05),且观察组各指标均低于对照组(P均0.05);观察组头痛、呕吐停止时间及体温、神经反射恢复正常时间均短于对照组(P均0.05),临床总有效率高于对照组(P0.05);两组治疗期间均未发生严重不良反应。结论六味地黄丸用于病毒性脑炎治疗,可有效降低患儿脑脊液淋巴细胞计数及血清炎性因子水平,临床疗效确切,治疗过程安全。
[Abstract]:Objective to observe the effect of Liuwei Dihuang Pill in the treatment of children with viral encephalitis. Methods Sixty-eight children with viral encephalitis were randomly divided into two groups: control group (n = 34) and observation group (n = 34). At the same time, acyclovir was injected intravenously, and the observation group was treated with Liuwei Dihuang pill for 3 weeks. Before and after treatment, cerebrospinal fluid (CSF) was taken to detect large lymphocytes, activated lymphocytes and plasma cells, and venous blood was taken to detect IL-1TNF- 伪, to record the time of improvement of clinical symptoms, to evaluate the clinical efficacy and to observe the adverse drug reactions. Results before treatment, large lymphocytes in cerebrospinal fluid (CSF) were activated in both groups. There was no significant difference in plasma cell count and serum IL-1TNF- 伪 level between the two groups (P < 0.05). After 3 weeks of treatment, the indexes in the two groups were lower than those before treatment (P 0.05), and the indexes in the observation group were lower than those in the control group (P 0.05), the headache, vomiting stopping time and body temperature in the observation group were lower than those in the control group (P 0.05). The recovery time of nerve reflex was shorter than that of the control group (P 0.05), and the total clinical effective rate was higher than that of the control group (P0.05). Conclusion Liuwei Dihuang pills can effectively reduce the number of cerebrospinal fluid lymphocytes and the level of serum inflammatory factors in children with viral encephalitis.
【作者单位】：河南省中医院;
【基金】：国家自然科学基金资助项目(81573919)
【分类号】：R272

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