MP抗体阳性对CVA患儿肺功能和预后的预测价值分析

发布时间：2018-08-20 07:31

【摘要】：目的分析MP抗体阳性对CVA患儿肺功能、炎症细胞因子水平和预后的影响。方法以2014年6月至2015年12月在本院接受治疗的咳嗽变异性哮喘患儿为研究对象。根据其实验室检测结果分为肺炎支原体阳性组(MP阳性组,55例)和肺炎支原体阴性组(MP阴性组,50例)。观察两组患儿肺功能指标、炎症细胞因子水平和预后的差异。结果两组患儿的肺功能指标存在明显差别:MP阳性组FVC、FEV1和FEV1/FVC等指标明显低于MP阴性组,差异具有统计学意义(P0.05);MP阳性组患儿的IL-10、IL-13和IL-1β等炎症细胞因子水平明显高于MP阴性组,差异具有统计学意义(P0.05);MP阴性组患儿生活质量各维度得分明显高于MP阳性组患儿,差异具有统计学意义(P0.05);MP阳性组患儿半年复发率明显高于MP阴性组,差异具有统计学意义(P0.05)。结论 MP抗体阳性的CVA患儿肺功能较差、炎症细胞因子水平较高,且预后和生活质量均受明显影响。
[Abstract]:Objective to analyze the effects of MP antibody positive on pulmonary function, inflammatory cytokines and prognosis in children with CVA. Methods Children with cough variant asthma treated in our hospital from June 2014 to December 2015 were studied. According to the results of laboratory tests, the patients were divided into mycoplasma pneumoniae positive group (MP positive group, 55 cases) and mycoplasma pneumoniae negative group (MP negative group, 50 cases). Pulmonary function, inflammatory cytokines and prognosis were observed. Results there was a significant difference in pulmonary function between the two groups. The levels of inflammatory cytokines such as IL-10, IL-13 and IL-1 尾 in the positive group of MP were significantly higher than those in the negative group of MP (P0.05), and the indexes of FEV1 and FEV1/FVC in the positive group were significantly lower than those in the group with negative MP. The difference was statistically significant (P0.05) the scores of QOL in MP negative group were significantly higher than those in MP positive group (P0.05), the semi-annual recurrence rate in MP positive group was significantly higher than that in MP negative group, and the difference was statistically significant (P0.05). Conclusion the pulmonary function of children with MP antibody positive CVA is poor, the level of inflammatory cytokines is higher, and the prognosis and quality of life are obviously affected.
【作者单位】：华中科技大学同济医学院附属武汉儿童医院;
【分类号】：R725.6

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