混合感染因素对难治性肺炎支原体肺炎的影响

发布时间：2018-08-20 17:57

【摘要】：目的了解混合感染因素对难治性肺炎支原体肺炎(RMPP)的作用及影响。方法收集并分析2013年1月至2015年12月286例RMPP患儿的病史资料。依据病原检测结果将患儿分为RMPP混合感染组和单纯感染组,比较两组患儿临床特征及实验室检查结果。结果混合感染组患儿热程和住院天数分别为12.5(11.0~14.0)d、12.00(9.0~14.0)d,均明显高于单纯感染组的11.0(9.0~13.0)d、10.0(8.0~12.0)d,差异均有统计学意义(P均0.01)。混合感染组患儿白细胞计数,中性粒细胞百分比,血小板计数,乳酸脱氢酶、C反应蛋白(CRP)40 mg/L、CRP100 mg/L及CK-MB升高发生率均高于单纯感染组,差异有统计学意义(P均0.05)。混合感染组气胸、呼吸衰竭发生率高于单纯感染组,差异均有统计学意义(P均0.05)。混合感染组血液系统损害、心肌损害、电解质紊乱发生率高于单纯感染组,差异均有统计学意义(P均0.05)。结论混合感染会使RMPP患儿发热时间延长,全身炎症反应加重,肺内外并发症发生率升高,并增加患儿的住院时间。
[Abstract]:Objective to investigate the effect of mixed infection factors on (RMPP) of refractory mycoplasma pneumoniae pneumonia. Methods from January 2013 to December 2015, 286 cases of RMPP were collected and analyzed. According to the results of pathogen detection, the children were divided into two groups: RMPP mixed infection group and simple infection group. The clinical characteristics and laboratory results of the two groups were compared. Results the fever course and hospitalization days in the mixed infection group were 12.5 (11.0 卤14.0) d (9.0 卤14.0) d, respectively, which were significantly higher than that in the simple infection group (11.0 (9.00.13.0) dago 10.0 (8.0 卤12.0) d) (all P 0.01). The incidence of leukocyte count, neutrophil percentage, platelet count, lactate dehydrogenase C-reactive protein (CRP) 40 mg / L CRP100 mg/L and CK-MB in the mixed infection group were significantly higher than those in the simple infection group (P 0.05). The incidence of pneumothorax and respiratory failure in mixed infection group was higher than that in simple infection group (P 0.05). The incidence of blood system damage, myocardial damage and electrolyte disturbance in mixed infection group was higher than that in pure infection group (P 0.05). Conclusion mixed infection can prolong the febrile time, aggravate the systemic inflammatory reaction, increase the incidence of intrapulmonary and extrapulmonary complications, and increase the hospitalization time of the children with RMPP.
【作者单位】：苏州大学附属儿童医院呼吸科;苏州大学附属儿童医院检验科;
【基金】：苏州市“科教兴卫”青年科技项目(No.KJXW2016019) 国家自然科学基金项目(No.81570016) 国家青年自然科学基金项目(No.81401296)
【分类号】：R725.6

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