蒡勃乳蛾消颗粒治疗小儿急性扁桃体炎外感风热证的临床研究

发布时间：2018-08-22 08:46

【摘要】：目的：验证蒡勃乳蛾消颗粒治疗小儿急性扁桃体炎(外感风热证)的有效性及安全性,从而为临床提供具有疏风清热、解毒利咽功效并保留中药汤剂特点的一种新制剂。方法：运用随机、双盲双模拟、阳性药平行对照、多中心临床研究的方法,将符合急性扁桃体炎(外感风热证)诊断标准的88例患儿分为试验组和对照组,试验组66例患儿服用蒡勃乳蛾消颗粒,对照组22例患儿服用小儿清咽颗粒,两组均以5天为1个疗程,服药1个疗程后,通过中医证候分级量化标准表,观察两组患儿治疗前后发热、咽喉肿痛等症状改善情况。结果：试验组疾病治愈率为66.67%,显效率为90.91%,病证治愈率为68.18%,显效率为90.91%；对照组疾病治愈率为31.82%,显效率为63.64%,病证治愈率为36.36%,显效率为63.64%,疾病疗效P0.05,病证疗效P0.05,两组疾病疗效、病证疗效比较有显著性差异,试验组总疗效优于对照组。两组患儿在咽痛改善时间方面比较有显著性差异(P0.05),试验组改善咽痛疗效优于对照组。退热时间方面,两组比较无显著性差异(P0.05),两组退热疗效相当。试验组、对照组患儿均未出现不良反应。结论：蒡勃乳峨消颗粒为治疗小儿急性扁桃体炎外感风热证安全有效的药物,在改善咽痛症状,疾病疗效、病证疗效方面比较优于对照组。
[Abstract]:Objective: to verify the efficacy and safety of burdock Bolu moxiao granule in the treatment of acute tonsillitis in children (external wind-heat syndrome), and to provide a new preparation with the function of clearing away wind and clearing heat, detoxifying and detoxifying pharynx, and retaining the characteristics of traditional Chinese medicine decoction. Methods: 88 children with acute tonsillitis (external wind-heat syndrome) were divided into experimental group and control group. 66 children in the test group were treated with burdock milk moxiao granules, and 22 children in the control group were given children's Qingyan granules. The two groups were treated with 5 days as a course of treatment. After taking one course of treatment, the TCM syndromes classification and quantification standard table were used. The symptoms of fever, throat swelling and pain were observed before and after treatment. Results: in the test group, the cure rate of disease was 66.67, the effective rate was 90.91, the cure rate of disease syndrome was 68.18 and the effective rate was 90.91.The cure rate of disease in control group was 31.82, the effective rate was 63.64, the cure rate of disease syndrome was 36.366,the effective rate of disease was 63.64, the curative effect of disease was P0.05, and the curative effect of disease syndrome was P0.05. There was significant difference in the curative effect between the two groups, and the total curative effect of the experimental group was better than that of the control group. There was significant difference in the improvement time of pharynx pain between the two groups (P0.05), and the curative effect of the experimental group was better than that of the control group. There was no significant difference in antipyretic time between the two groups (P0.05). There were no adverse reactions in both the experimental group and the control group. Conclusion: burdock Bolu E Xiao granule is a safe and effective drug for treating acute tonsillitis in children with external wind-heat syndrome. It is superior to the control group in improving the symptoms of pharynx, disease and disease.
【学位授予单位】：南京中医药大学
【学位级别】：硕士
【学位授予年份】：2012
【分类号】：R272

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