磷酸奥司他韦联合炎琥宁对儿童流感病毒感染患儿免疫功能及预后的影响分析
发布时间：2018-08-26 19:10
【摘要】：目的探究磷酸奥司他韦联合炎琥宁对儿童流感病毒感染患儿免疫功能及预后的影响分析。方法选择医院2015年7月-2016年2月收治的流感病毒感染患儿61例,采用随机、平行、双盲的方法分成联合组31例和对照组30例,联合组接受磷酸奥司他韦联合炎琥宁治疗,对照组仅接受磷酸奥司他韦治疗,观察两组患儿免疫功能改善及预后情况。结果经不同治疗后,联合组患儿发热消退、乏力缓解、肺部影像学积分及病毒核酸转阴时间分别为(7.45±1.49)d、(9.01±1.69)d、(1.64±0.59)分及(6.52±1.51)d,均低于对照组(9.17±2.31)d、(11.67±2.18)d、(2.71±0.92)分及(9.49±2.63)d,差异有统计学意义(P0.05);联合组CD_4~+T细胞、CD_8~+T细胞、CD_3~+T细胞、NK细胞比例均明显高于对照组,差异有统计学意义(P0.05);在预后方面,联合组治愈率及显效率分别为41.94%、51.61%,总有效率为93.55%,与对照组23.33%、50.00%及73.33%比较,差异有统计学意义(P0.05)。结论磷酸奥司他韦联合炎琥宁可以更好地提高流感病毒感染患儿的淋巴细胞亚群比例,提高免疫功能,改善临床症状及预后转归,值得推荐使用。
[Abstract]:Objective to investigate the effect of oseltamivir phosphate combined with Yanhuning on immune function and prognosis of children with influenza virus infection. Methods from July 2015 to February 2016, 61 children with influenza virus infection were randomly divided into two groups: the combined group (31 cases) and the control group (30 cases). The combined group was treated with oseltamivir phosphate combined with Yanhuning. The control group was only treated with oseltamivir phosphate. The immune function and prognosis of the two groups were observed. Results after different treatment, fever subsided and fatigue relieved in the combined group. The pulmonary imaging score and viral nucleic acid conversion time were (7.45 卤1.49) d, (9.01 卤1.69) d, (1.64 卤0.59) d and (6.52 卤1.51) d, respectively, which were significantly lower than those in the control group (9.17 卤2.31) d, (11.67 卤2.18) d, (2.71 卤0.92) and (9.49 卤2.63) d, respectively (P0.05). The difference was statistically significant (P0.05); the cure rate and marked effective rate of the combined group were 41.94 and 51.61.The total effective rate was 93.550.Compared with the control group 23.33g 50.00% and 73.33%, the difference was statistically significant (P0.05). Conclusion oseltamivir phosphate combined with Yanhuning can improve lymphocyte subsets, immune function, clinical symptoms and prognosis of children with influenza virus infection.
【作者单位】： 郑州市儿童医院新生儿内科;
【基金】：河南省医学科技攻关基金资助项目(201303034)
【分类号】：R725.1
，
本文编号：2205883
[Abstract]:Objective to investigate the effect of oseltamivir phosphate combined with Yanhuning on immune function and prognosis of children with influenza virus infection. Methods from July 2015 to February 2016, 61 children with influenza virus infection were randomly divided into two groups: the combined group (31 cases) and the control group (30 cases). The combined group was treated with oseltamivir phosphate combined with Yanhuning. The control group was only treated with oseltamivir phosphate. The immune function and prognosis of the two groups were observed. Results after different treatment, fever subsided and fatigue relieved in the combined group. The pulmonary imaging score and viral nucleic acid conversion time were (7.45 卤1.49) d, (9.01 卤1.69) d, (1.64 卤0.59) d and (6.52 卤1.51) d, respectively, which were significantly lower than those in the control group (9.17 卤2.31) d, (11.67 卤2.18) d, (2.71 卤0.92) and (9.49 卤2.63) d, respectively (P0.05). The difference was statistically significant (P0.05); the cure rate and marked effective rate of the combined group were 41.94 and 51.61.The total effective rate was 93.550.Compared with the control group 23.33g 50.00% and 73.33%, the difference was statistically significant (P0.05). Conclusion oseltamivir phosphate combined with Yanhuning can improve lymphocyte subsets, immune function, clinical symptoms and prognosis of children with influenza virus infection.
【作者单位】： 郑州市儿童医院新生儿内科;
【基金】：河南省医学科技攻关基金资助项目(201303034)
【分类号】：R725.1
，
本文编号：2205883
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